CYP2D6 genotype analysis of a Thai population: platform comparison
| Autor: | Natchaya Vanwong, Chonlaphat Sukasem, Monpat Chamnanphon, Nopphadol Nuntamool, Apichaya Puangpetch, Andrea Gaedigk, Yaowaluck Hongkaew |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pharmacology
AmpliChip CYP450 Test CYP2D6 Veterinary medicine Genotype Genetic Variation Locus (genetics) Sequence Analysis DNA Biology Thailand 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Cytochrome P-450 CYP2D6 Gene Frequency 030220 oncology & carcinogenesis Thai population Population Surveillance Genetic variation Genetics Molecular Medicine Humans Allele Genotyping |
| Zdroj: | Pharmacogenomics. 19(12) |
| ISSN: | 1744-8042 |
| Popis: | The highly polymorphic CYP2D6 gene locus leads to a wide range of enzyme activity. Since there are limited data for Thai, the major aim was to investigate CYP2D6 genetic variation in a large Thai population (n = 920). CYP2D6 genotyping was performed using four different platforms. Genotype call rates of the Luminex xTAG® and AmpliChip CYP450 test were 96.5% and 87.4%, respectively. Based on Luminex xTAG® data, the most common alleles and genotypes were *1 0 (49.6%), *1 (24.6%), *2 (10.8%), *5 (6.7%), *41 (6.5%) and *1/*10 (23.9%), *10/*10 (21.5%), *2/*10 (9.4%), *5/*10 (6.9%), *10/*41 (5.7%), respectively. Challenges and limitations of the platforms evaluated are discussed. These data add to our knowledge regarding interethnic variability in CYP2D6 activity and contribute to improving drug therapy in the Thai. |
| Databáze: | OpenAIRE |
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