Patients' perspectives on the derivation and use of organoids
| Autor: | Juli Bollinger, Mark Donowitz, Debra J. H. Mathews, Jeremy Sugarman, Elizabeth May |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Value (ethics) Biomedical Research Patients media_common.quotation_subject Disease Biology Biochemistry Medical care patient perspectives Interviews as Topic Young Adult Surveys and Questionnaires Report Genetics Institution Organoid Humans Gonads Aged media_common Medical education Ethical issues Brain Cell Biology Middle Aged ethics Human development (humanity) Organoids Female qualitative research Developmental Biology Qualitative research |
| Zdroj: | Stem Cell Reports |
| ISSN: | 2213-6711 |
| Popis: | Summary Organoid research is enhancing understanding of human development and diseases as well as aiding in medication development and selection, raising hopes for even more future therapeutic options. Nevertheless, this work raises important ethical issues and there is a paucity of data regarding patients' perspectives on them. We report on 60 interviews with adult patients or parents of pediatric patients from diverse disease populations who receive medical care at a major academic research institution in the United States. Interviewees expressed broad support for organoid development and use. However, patients viewed brain organoids, and sometimes gonadal organoids, as morally distinct; and some organoid research poses moral concerns. Nonetheless, patients generally understood the potential value of such research and approved of it, provided it was aimed at good intent and conducted with ethical oversight and a robust consent process. These data should help inform conceptual and policy deliberations about appropriate organoid use. Graphical abstract Highlights • Sixty in-depth patient interviews regarding organoid research and use • Interviewees expressed broad support for organoid development and use • Brain organoids are morally distinct, and some organoid research poses moral concern • Good intent, ethical oversight, and a robust consent process are required In this article, Bollinger and colleagues report on in-depth interviews with patients (or their parents) with diseases and conditions where organoid research is advancing scientific understanding and holds clinical translation potential, as well as with general outpatients. These data should inform ethics and policy deliberations. |
| Databáze: | OpenAIRE |
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