Frequent occurrence of low-level positive autoantibodies in chronic hepatitis C
| Autor: | Elizabeth McKinnon, Silvana Gaudieri, Pooja Deshpande, Michaela Lucas, Rosemary A. Ffrench, Margaret Hellard, Anna L. Wilkinson, Christine Bundell, Heidi E. Drummer |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Anti-nuclear antibody Hepatitis C virus Autoimmunity medicine.disease_cause Gastroenterology Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Clinical significance Aged Autoantibodies Autoimmune disease business.industry Autoantibody Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease 030104 developmental biology Antibodies Antinuclear 030220 oncology & carcinogenesis Cohort Female business |
| Zdroj: | Pathology. 52:576-583 |
| ISSN: | 0031-3025 |
| Popis: | Evidence of autoimmune disease associated with hepatitis C virus (HCV)-infection has important clinical implications. A systematic profile of these autoantibodies in relevant clinical cohorts relative to healthy controls is needed to better inform current standard of care for chronic hepatitis C. Samples from an Australian cohort of chronic HCV-infected subjects (n=127) were tested for the presence of 19 diagnostic autoantibodies and compared with data available from a control cohort representing a general Caucasian population (n=198). Chronic HCV-infected individuals had a greater number of autoantibodies than controls (p |
| Databáze: | OpenAIRE |
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