Synthesis and antioxidant activity evaluation of new hexahydropyrimido[5,4-c]quinoline-2,5-diones and 2-thioxohexahydropyrimido[5,4-c]quinoline-5-ones obtained by Biginelli reaction in two steps
| Autor: | Alain Xicluna, Jean-François Robert, Catherine Guyon, Laurence Nicod, Bernard Refouvelet, Arulraj Nadaradjane, Lhassane Ismaili |
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| Přispěvatelé: | Fonctions et dysfonctions épithéliales - UFC (EA 4267) (FDE), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC) |
| Rok vydání: | 2008 |
| Předmět: |
Magnetic Resonance Spectroscopy
Spectrophotometry Infrared DPPH Biginelli reaction Quinolones 010402 general chemistry 01 natural sciences Chemical synthesis Aldehyde Antioxidants chemistry.chemical_compound Drug Discovery Moiety Organic chemistry Pharmacology chemistry.chemical_classification MESH: Quinolones Hydroxyl Radical MESH: Magnetic Resonance Spectroscopy MESH: Spectrophotometry Infrared 010405 organic chemistry MESH: Antioxidants Organic Chemistry Quinoline Free Radical Scavengers General Medicine MESH: Hydroxyl Radical [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences 0104 chemical sciences 3. Good health chemistry Thiourea Ethyl acetoacetate MESH: Free Radical Scavengers |
| Zdroj: | European Journal of Medicinal Chemistry European Journal of Medicinal Chemistry, Elsevier, 2008, 43 (6), pp.1270-1275. ⟨10.1016/j.ejmech.2007.07.012⟩ |
| ISSN: | 0223-5234 1768-3254 |
| DOI: | 10.1016/j.ejmech.2007.07.012 |
| Popis: | International audience; New hexahydropyrimido[5,4-c]quinoline-2,5-diones and 2-thioxohexahydropyrimido[5,4-c]quinoline-5-ones were prepared in two steps from ethyl 4-phenyl-6-methyl-2-oxo tetrahydropyrimidine-5-carboxylates or 4-phenyl-6-methyl-2-thioxotetrahydropyrimidine-5-carboxylates, previously prepared by Biginelli reaction using appropriate aldehyde, urea derivatives and ethyl acetoacetate. Their antioxidant properties were evaluated by two methods: scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals and scavenging effect on hydroxyl radicals. The results show that the compounds containing thiourea moiety have better activity. |
| Databáze: | OpenAIRE |
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