Determination of Age-Dependent Reference Ranges for Coagulation Tests Performed Using Destiny Plus
| Autor: | Merve Zeytinli, Hüseyin Tarhan, Ozgur Cakmak, Hamit Yasar Ellidag, Mustafa Onur Öztan, Muhittin Serdar, Elif Merve Ari, Fatma Demet Arslan, Sureyya Hikmet Kozcu |
|---|---|
| Přispěvatelé: | Acibadem University Dspace |
| Rok vydání: | 2016 |
| Předmět: |
Prothrombin time
medicine.medical_specialty medicine.diagnostic_test business.industry Reference range 030204 cardiovascular system & hematology Fibrinogen Confidence interval Surgery 03 medical and health sciences 0302 clinical medicine Age Groups 030220 oncology & carcinogenesis Internal medicine Reference Ranges Pediatrics Perinatology and Child Health medicine Coagulation testing Blood Coagulation Tests business Volunteer Blood coagulation test Partial thromboplastin time medicine.drug Research Article |
| Zdroj: | Iranian Journal of Pediatrics |
| ISSN: | 2008-2142 |
| Popis: | Background In order to apply the right treatment for hemostatic disorders in pediatric patients, laboratory data should be interpreted with age-appropriate reference ranges. Objectives The purpose of this study was to determining age-dependent reference range values for prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen tests, and D-dimer tests. Materials and methods A total of 320 volunteers were included in the study with the following ages: 1 month - 1 year (n = 52), 2 - 5 years (n = 50), 6 - 10 years (n = 48), 11 - 17 years (n = 38), and 18 - 65 years (n = 132). Each volunteer completed a survey to exclude hemostatic system disorder. Using a nonparametric method, the lower and upper limits, including 95% distribution and 90% confidence intervals, were calculated. Results No statistically significant differences were found between PT and aPTT values in the groups consisting of children. Thus, the reference ranges were separated into child and adult age groups. PT and aPTT values were significantly higher in the children than in the adults. Fibrinogen values in the 6 - 10 age group and the adult age group were significantly higher than in the other groups. D-dimer levels were significantly lower in those aged 2 - 17; thus, a separate reference range was established. Conclusions These results support other findings related to developmental hemostasis, confirming that adult and pediatric age groups should be evaluated using different reference ranges. |
| Databáze: | OpenAIRE |
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