A flavonoid from medicinal plants blocks hepatitis B virus-e antigen secretion in HBV-infected hepatocytes
| Autor: | Eun Hwa Kang, Young Ik Lee, Min Soo Shin |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Hepatitis B virus
HBsAg Magnetic Resonance Spectroscopy Gene Products pol Virus Replication medicine.disease_cause Antiviral Agents Mass Spectrometry Virus Cell Line Immune tolerance chemistry.chemical_compound Ellagic Acid Antigen Virology medicine Humans Hepatitis B e Antigens Pharmacology Hepatitis B Surface Antigens Molecular Structure biology Plant Extracts virus diseases biology.organism_classification digestive system diseases Phyllanthus HBeAg Hepadnaviridae chemistry Hepatocytes Ellagic acid |
| Zdroj: | Antiviral Research. 67:163-168 |
| ISSN: | 0166-3542 |
| DOI: | 10.1016/j.antiviral.2005.06.005 |
| Popis: | A flavonoid molecule that showed a unique anti-HBV function was isolated from Phyllanthus urinaria. The molecular formula was determined as C14H6O8 based on FAM-MS analysis and the structure was determined by NMR. The identified flavonoid molecule, ellagic acid, showed unique anti-HBV functions. Ellagic acid did not inhibit either HBV polymerase activity, HBV replication or block HBsAg secretion. Rather, ellagic acid blocks effectively HBeAg secretion in HepG2 2.2.15 cells (IC50 = 0.07 μg/ml). Since HBeAg is involved in immune tolerance during HBV infection, ellagic acid, a newly identified functional anti-HBV compound, may be a new candidate therapeutic against immune tolerance in HBV-infected individuals. |
| Databáze: | OpenAIRE |
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