Effect of Glucagon on Glucose Output from Bivascularly Perfused Rat Liver
| Autor: | Osamu Mokuda, Tadasu Ikeda, T. Hoshino, Hiroto Mashiba, Tatsuo Takeuchi, Masato Tominaga, M. Honda |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Glycogenolysis Endocrinology Diabetes and Metabolism Biology Glucagon Endocrinology Internal medicine Perfused liver Internal Medicine medicine Animals Pancreatic hormone Portal Vein Rats Inbred Strains General Medicine Glucose output Rats Perfusion Glucose medicine.anatomical_structure Liver Basal (medicine) Rat liver Artery |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 94:383-386 |
| ISSN: | 1439-3646 0947-7349 |
| DOI: | 10.1055/s-0029-1210925 |
| Popis: | Glucose output was investigated in bivascularly perfused rat liver. Flow rate was 1 ml/min/g from hepatic artery and 2 ml/min/g from portal vein. Basal glucose output (130 +/- 30 microM/min) from bivascularly perfused liver was significantly (p less than 0.02) higher than that (80 +/- 20 microM/min) from usual monovascularly perfused (3 ml/min/g from portal vein) liver. However, glucagon-induced (1 ng/ml) increment in glucose output from bivascularly perfused liver 589 +/- 127 microM/30 min) was not significantly different from that (630 +/- 127 microM/30 min) of monovascularly perfused liver. These results suggest that glucagon-dependent glucose output was similar in monovascularly and bivascularly perfused rat liver, and that arterial blood supply may have some role in glycogenolysis in the perfused rat liver. |
| Databáze: | OpenAIRE |
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