Manifestations and Outcomes of Patients with Parkinson’s Disease and Serious Infection in the Emergency Department
| Autor: | Chia-Te Kung, Fu-Cheng Chen, Hsien-Hung Cheng, Yun-Ru Lai, Chih-Min Su, Nai-Wen Tsai, Sheng-Yuan Hsiao, C.-R. Huang, Cheng-Hsien Lu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Article Subject lcsh:Medicine Comorbidity Infections General Biochemistry Genetics and Molecular Biology Sepsis 03 medical and health sciences 0302 clinical medicine Bandemia Internal medicine Humans Medicine Hospital Mortality Infectious disease (athletes) Aged Retrospective Studies General Immunology and Microbiology business.industry lcsh:R Organ dysfunction Parkinson Disease 030208 emergency & critical care medicine Retrospective cohort study General Medicine Emergency department medicine.disease Hospitalization Female medicine.symptom Emergency Service Hospital business Empiric therapy Biomarkers 030217 neurology & neurosurgery Research Article |
| Zdroj: | BioMed Research International, Vol 2018 (2018) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Background. Several comorbidities contribute to an increased risk of infections in Parkinson’s disease (PD) as the disease progresses. However, few studies have examined the correlation between sepsis and PD. Aim. The aim of this study is to disclose the presentation and outcome of serious infection in patients with PD in the emergency department. Methods. This retrospective cohort study enrolled patients with PD who had serious infection and were admitted to the emergency department between January 2007 and December 2013. For clinical comparison, we compared the clinical features, laboratory data, and outcomes with those of age- and sex-matched patients who had serious infection but not PD. Results. There were a total of 1,200 episodes of infected PD patients and 2,400 age- and sex-matched infected patients without PD as disease controls. PD patients had fewer comorbidities and lower severity of infectious disease but longer hospital stays than control group patients. The incidences of respiratory tract and urinary tract infections were higher in PD patients. The levels of inflammatory and organ dysfunction biomarkers in PD were lower and compatible with the severity of infectious disease. A total of 86 (7.2%) infected PD patients died during the 28-day admission compared to 339 (14.1%) in non-PD patients. Serum C-reactive protein, bandemia, and lactate could be used to predict mortality in infected PD patients. Conclusions. In infected patients with PD, respiratory and urinary tract infections were the two most common infectious sources. Empiric therapy based on experience could treat both respiratory and urinary tract infections. Early diagnosis and treatment are essential for survival. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |