A consensus research agenda for optimising nasal drug delivery
| Autor: | Pierre Lambert, Fabio Sonvico, Rene Bommer, Grazia Caivano, Marie Hellfritzsch, Wilbur de Kruijf, Francesca Schiaretti, Gerallt Williams, Marie Trenkel, Alain Regard, Laurent Vecellio, Regina Scherließ, Jonathan Goole, Ben Forbes |
|---|---|
| Přispěvatelé: | King‘s College London, PharmAccel Consulting, Moos, Université libre de Bruxelles (ULB), Department of Pharmaceutics and Biopharmaceutics, Kiel University, Medspray BV, Ecole Polytechnique de Bruxelles, Chiesi Farmaceutici, Nemera Insight Innovation Center, La Verpilière, Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 (CEPR), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), Aptar Pharma, Le Vaudreuil, Dipartimento di Farmacia,Universita` di Parma and INFM, University of Parma = Università degli studi di Parma [Parme, Italie], Le Pennec, Deborah, Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli studi di Parma = University of Parma (UNIPR) |
| Jazyk: | francouzština |
| Rok vydání: | 2020 |
| Předmět: |
Drug deposition
Special populations [SDV.BIO]Life Sciences [q-bio]/Biotechnology Consensus Pharmaceutical Science 02 engineering and technology Sciences de l'ingénieur 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Drug Delivery Systems Medicine Humans ComputingMilieux_MISCELLANEOUS Administration Intranasal business.industry Research Research needs Nose to brain 021001 nanoscience & nanotechnology 3. Good health [SDV.BIO] Life Sciences [q-bio]/Biotechnology Important research Risk analysis (engineering) Pharmaceutical Preparations Drug delivery Sciences pharmaceutiques Nasal Cavity 0210 nano-technology Critical quality attributes business |
| Zdroj: | Expert opinion on drug delivery Expert Opinion on Drug Delivery Expert Opinion on Drug Delivery, Taylor & Francis, 2020, 17 (2), pp.127-132. ⟨10.1080/17425247.2020.1714589⟩ Expert Opinion on Drug Delivery, 2020, 17 (2), pp.127-132. ⟨10.1080/17425247.2020.1714589⟩ |
| ISSN: | 1742-5247 1744-7593 |
| DOI: | 10.1080/17425247.2020.1714589⟩ |
| Popis: | Nasal drug delivery has specific challenges which are distinct from oral inhalation, alongside which it is often considered. The next generation of nasal products will be required to deliver new classes of molecule, e.g. vaccines, biologics and drugs with action in the brain or sinuses, to local and systemic therapeutic targets. Innovations and new tools/knowledge are required to design products to deliver these therapeutic agents to the right target at the right time in the right patients. We report the outcomes of an expert meeting convened to consider gaps in knowledge and unmet research needs in terms of (i) formulation and devices, (ii) meaningful product characterization and modeling, (iii) opportunities to modify absorption and clearance. Important research questions were identified in the areas of device and formulation innovation, critical quality attributes for different nasal products, development of nasal casts for drug deposition studies, improved experimental models, the use of simulations and nasal delivery in special populations. We offer these questions as a stimulus to research and suggest that they might be addressed most effectively by collaborative research endeavors. |
| Databáze: | OpenAIRE |
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