US28 actions in HCMV infection: lessons from a versatile hijacker
| Autor: | J. M. Boomker, M. J. A. van Luyn, T. H. The, L. F. M. H. de Leij, M. C. Harmsen |
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| Rok vydání: | 2005 |
| Předmět: |
Human cytomegalovirus
Chemokine Arteriosclerosis NF-KAPPA-B Myocytes Smooth Muscle Cytomegalovirus NEUTROPHIL TRANSENDOTHELIAL MIGRATION Computational biology Biology Muscle Smooth Vascular HUMAN CYTOMEGALOVIRUS-INFECTION Viral Proteins Chemokine receptor Immune system Muscle cell migration Virology Virus latency medicine Humans Chemokine CX3CL1 MONOCYTE CHEMOATTRACTANT PROTEIN-1 Membrane Proteins SARCOMA-ASSOCIATED HERPESVIRUS IMMUNODEFICIENCY-VIRUS TYPE-1 BETA-CHEMOKINE RECEPTOR medicine.disease ENDOTHELIAL-CELLS Chemokines CX3C Virus Latency PROTEIN-COUPLED RECEPTOR Infectious Diseases Chemokine binding Cytomegalovirus Infections biology.protein MUSCLE-CELL MIGRATION Receptors Chemokine Signal transduction Signal Transduction |
| Zdroj: | Reviews in Medical Virology. 15:269-282 |
| ISSN: | 1099-1654 1052-9276 |
| Popis: | Mimicking host proteins is a strategy adopted by several herpesviruses to exploit the host cell for their own benefit. In this respect the human cytomegalovirus (HCMV) chemokine receptor homologue US28, has been extensively studied. Molecular pirates such as US28 can teach us about crucial events in HCMV infection and may either offer a potential target for antiviral therapy or provide an alternative strategy to immune suppression. Despite elaborate research into the chemokine binding affinity, signalling properties, intracellular trafficking and expression kinetics of US28, a solid hypothesis about the role of US28 in HCMV infection has not yet been proposed. It appears that US28 may behave as a molecular pirate that employs smart strategies for cell entry, host gene regulation and immune evasion. This review will elaborate on these aspects of US28 biology and discuss possible implications for HCMV infection. Copyright (c) 2005 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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