Aryl Hydrocarbon Hydroxylase Induction by Polycyclic Hydrocarbons: Simple Autosomal Dominant Trait in the Mouse
| Autor: | Daniel W. Nebert, F. M. Goujon, Jacques E. Gielen |
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| Rok vydání: | 1972 |
| Předmět: |
Male
Oxygenase Stereochemistry Gestational Age Mice Inbred Strains Endogeny Drug action Biology medicine.disease_cause General Biochemistry Genetics and Molecular Biology Mixed Function Oxygenases Mice Fetus Pregnancy medicine Animals Maternal-Fetal Exchange Molecular Biology Crosses Genetic Genes Dominant chemistry.chemical_classification Genetic Variation Autosomal dominant trait General Medicine Metabolism Hydrocarbons Phenotype Enzyme Animals Newborn Biochemistry chemistry Enzyme Induction Microsomes Liver Hybridization Genetic Female Polycyclic Hydrocarbons Carcinogenesis Injections Intraperitoneal Methylcholanthrene |
| Zdroj: | Nature New Biology. 236:107-110 |
| ISSN: | 2058-1092 0090-0028 |
| DOI: | 10.1038/newbio236107a0 |
| Popis: | MANY mixed function1 oxygenases are membrane-bound multicomponent enzyme systems which require NADPH and molecular oxygen for the oxidative metabolism of polycyclic hydrocarbons, drugs and insecticides, as well as numerous lipophilic endogenous substrates2–4. Any day to day fluctuations in these enzyme activities may therefore influence the intensity and duration of drug action and also the rate of metabolism of chemical carcinogens, insecticides and many normal body substrates. |
| Databáze: | OpenAIRE |
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