Prenatal over‐ and undernutrition differentially program small intestinal growth, angiogenesis, absorptive capacity, and endocrine function in sheep
| Autor: | Mette Olaf Nielsen, Anne Marie Dixen Axel, Prabhat Khanal, V.S. Elbrønd, Sina Safayi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Physiology Angiogenesis medicine.medical_treatment Neovascularization Physiologic prenatal malnutrition Endocrine System Ileum 030204 cardiovascular system & hematology Biology lcsh:Physiology Jejunum 03 medical and health sciences angiogenesis Overnutrition 0302 clinical medicine Pregnancy Physiology (medical) Internal medicine Intestine Small medicine Animals Insulin Endocrine system intestinal development Original Research Sheep postnatal overfeeding lcsh:QP1-981 Malnutrition Fasting medicine.disease Disease Models Animal medicine.anatomical_structure Endocrinology Intestinal Absorption Prenatal Exposure Delayed Effects Duodenum Female Landbruks- og Fiskerifag: 900::Landbruksfag: 910::Fôring: 918 [VDP] absorption 030217 neurology & neurosurgery |
| Zdroj: | Physiological Reports e14498 Khanal, P, Anne, A M, Safayi, S, Elbrønd, V S & Nielsen, M O 2020, ' Prenatal over-and undernutrition differentially program small intestinal growth, angiogenesis, absorptive capacity, and endocrine function in sheep ', Physiological Reports, vol. 8, no. 12, e14498 . https://doi.org/10.14814/phy2.14498 Khanal, P, Axel, A M D, Safayi, S, Elbrønd, V S & Nielsen, M O 2020, ' Prenatal over- and undernutrition differentially program small intestinal growth, angiogenesis, absorptive capacity, and endocrine function in sheep ', Physiological Reports, vol. 8, no. 12, e14498 . https://doi.org/10.14814/phy2.14498 Physiological Reports, Vol 8, Iss 12, Pp n/a-n/a (2020) |
| DOI: | 10.14814/phy2.14498 |
| Popis: | The aim was to test the hypothesis that prenatal under‐ and overnutrition in late gestation can program small intestinal (SI) growth, angiogenesis, and endocrine function to predispose for a hyperabsorptive state, thereby increasing the susceptibility to the adverse effects of an early postnatal obesogenic diet. Twin‐pregnant ewes were exposed to adequate (NORM), LOW (50% of NORM), or HIGH (150% energy and 110% protein of NORM) diets through the last trimester (term ~147 days). From 3 days to 6 months of age, their lambs were fed either a moderate (CONV) or a high‐carbohydrate high‐fat (HCHF) diet. At 6 months of age, responses in plasma metabolites and insulin to refeeding after fasting were determined and then different segments of the SI were sampled at autopsy. Prenatal overnutrition impacts were most abundant in the duodenum where HIGH had increased villus amplification factor and lowered villi thickness with increased IRS‐1 and reduced GH‐R expressions. In jejunum, HIGH lambs had an increased expression of Lactate gene and amplified when exposed to HCHF postnatally. Specifically, in LOW, sensitivity to HCHF was affected in ileum. Thus, the mismatching LOW‐HCHF nutrition increased expressions of angiogenic genes (VEGF, VEGF‐R1, ANGPT1, RTK) and increased mucosa layer (tunica mucosa) thickness but reduced muscle layer (Tunica muscularis) thickness. The SI is a target of prenatal nutritional programming, where late gestation overnutrition increased and shifted digestive capacity for carbohydrates toward the jejunum, whereas late gestation undernutrition predisposed for ileal angiogenesis and carbohydrate and fat hyperabsorptive capacity upon subsequent exposure to postnatal obesogenic diet. The small intestine is a target of prenatal nutritional programming, where late gestation overnutrition increased and shifted digestive capacity for carbohydrates toward the jejunum. Late gestation undernutrition predisposed for ileal angiogenesis and carbohydrate and fat hyperabsorptive capacity upon subsequent exposure to postnatal obesogenic diet. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|