Coyolosa, a new hypoglycemic from Acrocomia mexicana
| Autor: | Rosa M Pérez G., Cuauhtemoc Pérez G, Rosario Vargas S., Salud Pérez G, Miguel A. Zavala S |
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| Rok vydání: | 1997 |
| Předmět: |
Steric effects
Plants Medicinal Chloroform Plant Extracts Stereochemistry Methanol Substituent Blood sugar Mice Inbred Strains Tetrahydropyran Plant Roots Rats Mice chemistry.chemical_compound chemistry Acrocomia mexicana Animals Hexanes Hypoglycemic Agents Molecular Medicine Spectral analysis Rats Wistar General Pharmacology Toxicology and Pharmaceutics |
| Zdroj: | Pharmaceutica Acta Helvetiae. 72:105-111 |
| ISSN: | 0031-6865 |
| DOI: | 10.1016/s0031-6865(96)00019-2 |
| Popis: | From the methanol extract of the Arocomia mexicana root a new tetrahydropyrane compound was isolated. Its skeletal structure and relative stereochemistry were established by spectral analysis. Substituent effects have been determined with the hope of providing information about steric interactions and conformation of tetrahydropyran derivatives and carbohydrates. The extract showed a significant blood sugar lowering effect on normal and alloxan-diabetic mice when administered at 2.5 to 40 mg/kg i.p. doses, and exhibited a dose-dependent response in the mice models. |
| Databáze: | OpenAIRE |
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