Red blood cell transfusion-induced non-transferrin-bound iron promotes Pseudomonas aeruginosa biofilms in human sera and mortality in catheterized mice
| Autor: | Elizabeth A. Godbey, Sheila Bandyopadhyay, Eldad A. Hod, Kevin A Prestia, Kevin P. Francis, Andrea R Slate, Francesca La Carpia, Boguslaw S. Wojczyk |
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| Rok vydání: | 2021 |
| Předmět: |
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Blood transfusion Erythrocytes medicine.medical_treatment Iron Red Blood Cell Transfusion Virulence medicine.disease_cause Article Microbiology Mice Medicine Animals Humans chemistry.chemical_classification business.industry Pseudomonas aeruginosa Biofilm Hematology Survival Analysis Healthy Volunteers Bioavailability chemistry Transferrin Biofilms business Erythrocyte Transfusion |
| Zdroj: | Br J Haematol |
| ISSN: | 1365-2141 |
| Popis: | Transfusion of storage-damaged red blood cells (RBCs) increases non-transferrin-bound iron (NTBI) levels in humans. This can potentially enhance virulence of microorganisms. In this study, Pseudomonas aeruginosa replication and biofilm production in vitro correlated with NTBI levels of transfused subjects (R2 = 0·80; P |
| Databáze: | OpenAIRE |
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