Qualitative mucin disorders in patients with primary Sjögren's syndrome:a literature review
Autor: | Francesca Candelori, Roberta Priori, L. Mastromanno, L Weiss, Rita Businaro, Antonio Greco, A Riccio, Massimo Fusconi, Isotta Musy, M. De Vincentiis |
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Rok vydání: | 2021 |
Předmět: |
squamous cell carcinoma
Exocrine gland Saliva Spinnbarkeit MUC1 Disease Review MUC5B Xerostomia Salivary Glands oral diagnosis mucin stomatognathic system Medicine primary Sjögren's syndrome MUC7 sulphate oligosaccharides Humans General Dentistry Pathological UNESCO:CIENCIAS MÉDICAS Oral Medicine and Pathology business.industry mouth neoplasms Mucin Mucins Dry mouth stomatognathic diseases medicine.anatomical_structure Sjogren's Syndrome Otorhinolaryngology Immunology Surgery medicine.symptom business |
Zdroj: | Fusconi, M., Candelori, F., Weiss, L., Riccio, A., Priori, R., Businaro, R., Mastromanno, L., Musy, I., de Vincentiis, M., & Greco, A. (2021). Qualitative mucin disorders in patients with primary Sjögren’s syndrome: a literature review. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e71-e77). Medicina Oral, S.L. https://doi.org/10.4317/medoral.23996 Medicina Oral, Patología Oral y Cirugía Bucal |
Popis: | Background It is a common opinion that Primary Sjögren Syndrome (pSS) damages the exocrine glands and determines the reduction of secreted saliva, some studies show that there are qualitative anomalies of the mucins produced in saliva, including MUC7, MUC5B, MUC1. The purpose of this study is to trace all the information useful to establish whether there is a qualitative or quantitative defect of the mucins in the pSS. Material and Methods We reviewed the literature by looking for publications relevant to the topic in electronic databases. Sixteen articles met the search criteria. The studies were divided into two categories, those that studied the rheological characteristics of the saliva and those that studied the structural and / or metabolism modifications of the muciparous cells in the salivary glands. Results in Patients with pSS, xerostomia and the reduction of salivary spinnbarkeit are only partially related to the reduction of the unstimulated salivary flow. In pSS, pathological alterations of mucins’ chemical-physical properties prevail as a cause of the clinical characteristics. Moreover, in pSS there are structural and metabolism changes in salivary glands’ muciparous cells. Conclusions There is much evidence that supports the presence of qualitative alterations in the saliva’s rheological properties in Patients with pSS, and these are the main cause, more than the reduction of the unstimulated salivary flow, of the disease clinical characteristics - dry mouth and complications in the oral cavity. Therefore we propose to add to the classification criteria of pSS also a qualitative test of salivary glycoproteins. Key words:Primary Sjögren's syndrome, mucin, MUC7, MUC5B, MUC1, sulphate oligosaccharides. |
Databáze: | OpenAIRE |
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