Effect of the P2Y12antagonist ticagrelor on neointimal hyperplasia in a rabbit carotid anastomosis model
| Autor: | Ahmet Hakan Vural, Tamer Turk, Ulviye Yalcinkaya, Suleyman Surer, Cuneyt Eris, Nihal Y. Gul, Senol Yavuz, Mehmet Tuğrul Göncü, Faruk Toktaş, Derih Ay |
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| Přispěvatelé: | Uludağ Üniversitesi/Veterinerlik Fakültesi/Klinik Bilimler Bölümü., Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı., Gül, Nihal Yaşar, Yalçınkaya, Ulviye, AAH-8924-2021 |
| Rok vydání: | 2014 |
| Předmět: |
Single drug dose
Ticagrelor Antithrombocytic agent Adenosine Intimal hyperplasia Cardiac & cardiovascular systems Unclassified drug Biopsy Purinergic P2Y receptor antagonists medicine.medical_treatment Injury Rabbit Disease models animal Artery intima proliferation Animal tissue Receptors purinergic P2Y12 Purinergic P2Y12 receptor Restenosis Recurrence Pathology Recurrent disease Carotid Stenosis Common carotid artery Saline Priority journal Neointimal hyperplasia Analogs and derivatives Purinergic P2Y12 receptor antagonist Purinergic P2 receptor antagonist Tunica intima Immunohistochemistry Clopidogrel Carotid arteries Blood medicine.anatomical_structure Dose-response relationship drug Female Rabbits Anastomosis surgical Cardiology and Cardiovascular Medicine medicine.drug Pulmonary and Respiratory Medicine medicine.medical_specialty Anastomosis Urology Respiratory system Article Neointima Platelet aggregation inhibitors medicine.artery Dose response medicine Animals Animal model Drug dose comparison Animal experiment New Zealand white (rabbit) Rabbit model Hyperplasia Drug effects Animal Disease model business.industry Artery anastomosis Platelet Aggregation Inhibitors Purinergic P2Y receptor antagonist Thrombosis Nonhuman medicine.disease Surgery Drug efficacy Cardiovascular system & cardiology Metabolism Transforming growth factor beta business Controlled study Carotid artery |
| Zdroj: | Interactive CardioVascular and Thoracic Surgery. 19:198-204 |
| ISSN: | 1569-9285 1569-9293 |
| Popis: | OBJECTIVES: In the present study, we aimed to deterimine the dose-related effects of ticagrelor, the first reversible inhibitor of the P2Y(12) receptor, found in smooth muscle cells as well as platelets, during neointimal hyperplasia in a rabbit carotid anastomosis model. METHODS: This study was an experimental, prospective, randomized controlled study including 20 New Zealand white female rabbits (6-months old; weighing 2300 +/- 300 g). Under general anaesthesia, the rabbits underwent transection of the right carotid artery and subsequent anastomosis of both ends. The study animals were divided into the following 4 groups: T1 (ticagrelor 5 mg/kg, orally, daily), T2 (ticagrelor 10 mg/kg, orally, daily), T3 (ticagrelor 20 mg/kg, orally, daily) and control (no ticagrelor treatment). The single oral doses were administered in phosphate-buffered saline. The control group received sterile phosphate-buffered saline (2 ml/kg/day, orally) for 3 weeks postoperatively. At the end of the study, the animals were killed, and the anastomosed segment of the right carotid artery and part of the left carotid artery were excised from each animal. Antibodies against transforming growth factor-beta were used in staining of arterial sections, which was followed by histomorphological and immunohistochemical studies. RESULTS: The median intimal thickness (2.0 +/- 0.14 m left vs 73.4 +/- 35.8 m anastomosed right arteries; P |
| Databáze: | OpenAIRE |
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