D-xylose absorption and disposition in patients with moderately impaired renal function
| Autor: | Gary L. Hubler, Ewelina M Worwag, Ellen M Jansyn, Arthur J. Atkinson, Robert M. Craig, Donald F. Kirby |
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| Rok vydání: | 1987 |
| Předmět: |
Adult
Male medicine.medical_specialty Metabolic Clearance Rate Urology Renal function Absorption (skin) Xylose absorption Models Biological Impaired renal function Malabsorption Syndromes Oral administration Internal medicine medicine Humans Pharmacology (medical) In patient Aged Pharmacology Volume of distribution Xylose business.industry Middle Aged Normal limit Kinetics Endocrinology Intestinal Absorption Female Kidney Diseases business Glomerular Filtration Rate |
| Zdroj: | Clinical pharmacology and therapeutics. 41(3) |
| ISSN: | 0009-9236 |
| Popis: | D-Xylose kinetics were studied after oral and intravenous administration to 10 patients with impaired renal function, three of whom were being evaluated for intestinal malabsorption. The 0.32 ± 0.06 L/kg (mean ± SD) distribution volume of D-xylose in patients with uncomplicated renal impairment was larger than the value of 0.23 ± 0.04 L/kg that we reported previously for normal subjects (P < 0.01). Renal clearance was also reduced, averaging 87% of glomerular filtration rate estimated from creatinine clearance, so that the elimination-phase half-life was prolonged to 138 ± 39 minutes from 75 ± 11 minutes in normal individuals (P < 0.01). The 25 gm oral D-xylose dose was 77.4% ± 14.8% absorbed in the patients with uncomplicated renal impairment, similar to the 69.4% ± 13.6% absorption reported in normal individuals. However, the absorption half-life was prolonged from 31 ± 12 minutes in normal subjects to a value of 62 ± 23 minutes (P < 0.02). Of the usual clinical indexes of D-xylose absorption, the serum concentration measured 1 hour after the oral dose was best correlated with the extent of D-xylose absorption (r = 0.76; P < 0.01), and the standard lower normal limit of 0.2 mg/ml was satisfactory. Clinical Pharmacology and Therapeutics (1987) 41, 351–357; doi:10.1038/clpt.1987.38 |
| Databáze: | OpenAIRE |
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