[Preparation and chiral recognition of heterosubstituted amylose derivatives-based chiral stationary phases]
| Autor: | Shouwan Tang, Sufei Lin, Jieyu Ma, Baocun Wang, Minghui Bao |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Chromatography Chemistry General Chemical Engineering Organic Chemistry Regioselectivity Chiralpak AD Aminopropyl silica gel Polysaccharide Biochemistry High-performance liquid chromatography Chiral resolution Analytical Chemistry chemistry.chemical_compound Amylose Electrochemistry Organic chemistry Chiral derivatizing agent |
| Zdroj: | Se pu = Chinese journal of chromatography. 35(6) |
| ISSN: | 1000-8713 |
| Popis: | Two novel amylose derivatives, namely amylose 2-benzoate-3-(4-methylphenylcarbamate)-6-(3,5-dichlorophenylcarbamate) and amylose 2-benzoate-3-(3,5-dichlorophenylcarbamate)-6-(4-methylphenylcarbamate), were prepared utilizing a serial regioselective process. After coated onto aminopropyl silica gel, they were utilized as chiral stationary phases (CSPs) for high performance liquid chromatography. Investigations indicated that the CSPs exhibited characteristic chiral recognition and their chiral recognition abilities were much higher than those of amylose tris(3,5-dichlorophenylcarbamate) (ADCPC), a homosubstituted derivative. The nature and position of the substituents at 3-, and 6-positions of a glucose unit had great influence on the chiral resolution abilities of the amylose derivatives. Some chiral compounds which were not effectively resolved on the commercial column Chiralpak AD were effectively separated on the new CSPs. Moreover, with all the eight tested racemates resolved, amylose 2-benzoate-3-(4-methylphenylcarbamate)-6-(3,5-dichlorophenylcarbamate) exhibited relatively high chiral recognition and might be a potential useful CSP. |
| Databáze: | OpenAIRE |
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