Peripheral nociceptor sensitization mediates allodynia in patients with distal symmetric polyneuropathy
| Autor: | Frida Leonetti, Maria Teresa Petrucci, Andrea Truini, Claudio Cartoni, Milvia Casato, Giorgio Cruccu, G. Di Stefano, Mario Pergolini, S. La Cesa, Antonella Biasiotta, Caterina Leone |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Neurology Laser-Evoked Potentials Pain Nerve Fibers Myelinated Polyneuropathies painful neuropathy Evoked Potentials Somatosensory Physical Stimulation medicine Humans Prospective Studies Sensitization allodynia medicine.diagnostic_test business.industry Nociceptors laser evoked potentials medicine.anatomical_structure Allodynia Nociception Hyperalgesia Anesthesia Neuropathic pain Nociceptor Nerve conduction study Neurology (clinical) medicine.symptom business |
| Zdroj: | Journal of Neurology. 260:761-766 |
| ISSN: | 1432-1459 0340-5354 |
| DOI: | 10.1007/s00415-012-6698-9 |
| Popis: | Patients with painful neuropathy frequently complain of pain in response to normally non-painful brushing, namely dynamic mechanical allodynia. Despite many animal studies suggesting that allodynia arises when the spontaneous firing in damaged nociceptive afferents sensitise second-order nociceptive neurons to Aβ-fibre input, no studies have sought to confirm this mechanism by investigating Aβ-fibre sparing in human patients with allodynia. In this study we compared data from Aβ-fibre-mediated nerve conduction studies and nociceptive-fibre-mediated laser-evoked potentials (LEPs) in 200 patients with distal symmetric polyneuropathy (114 with neuropathic pain, 86 without). Of the 114 patients with painful neuropathy studied, 44 suffered from allodynia. Whereas no statistical difference was found in nerve conduction study data between patients with and without allodynia, LEP amplitudes were larger in patients with allodynia than in those without (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink