Treatment with tianeptine induces antidepressive-like effects and alters the neurotrophin levels, mitochondrial respiratory chain and cycle Krebs enzymes in the brain of maternally deprived adult rats
| Autor: | Giselli Scaini, Débora B. Tomaz, João Quevedo, Franciela P. Della, Altamir Rocha Antunes, Meline O. S. Morais, Helena M. Abelaira, Gislaine Z. Réus, Maria Augusta B Dos Santos, Emilio L. Streck |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Thiazepines Citric Acid Cycle Hippocampus Nucleus accumbens Biochemistry Amygdala Open field Electron Transport Cellular and Molecular Neuroscience Internal medicine Nerve Growth Factor medicine Animals Citrate synthase Tianeptine Rats Wistar biology Chemistry Brain-Derived Neurotrophic Factor Maternal Deprivation Brain Antidepressive Agents Mitochondria Rats Succinate Dehydrogenase Mitochondrial respiratory chain medicine.anatomical_structure Endocrinology nervous system biology.protein Female Neurology (clinical) Neurotrophin medicine.drug |
| Zdroj: | Metabolic Brain Disease. 28:93-105 |
| ISSN: | 1573-7365 0885-7490 |
| Popis: | Maternally deprived rats were treated with tianeptine (15 mg/kg) once a day for 14 days during their adult phase. Their behavior was then assessed using the forced swimming and open field tests. The BDNF, NGF and energy metabolism were assessed in the rat brain. Deprived rats increased the immobility time, but tianeptine reversed this effect and increased the swimming time; the BDNF levels were decreased in the amygdala of the deprived rats treated with saline and the BDNF levels were decreased in the nucleus accumbens within all groups; the NGF was found to have decreased in the hippocampus, amygdala and nucleus accumbens of the deprived rats; citrate synthase was increased in the hippocampus of non-deprived rats treated with tianeptine and the creatine kinase was decreased in the hippocampus and amygdala of the deprived rats; the mitochondrial complex I and II-III were inhibited, and tianeptine increased the mitochondrial complex II and IV in the hippocampus of the non-deprived rats; the succinate dehydrogenase was increased in the hippocampus of non-deprived rats treated with tianeptine. So, tianeptine showed antidepressant effects conducted on maternally deprived rats, and this can be attributed to its action on the neurochemical pathways related to depression. |
| Databáze: | OpenAIRE |
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