All-Trans Retinoic Acid as an Alternative to Chemotherapy in the Treatment of Acute Promyelocyte Leukemia
| Autor: | Thomas Kühne, Osterwalder B, Paul Imbach, Signer E |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Acute promyelocytic leukemia
Oncology medicine.medical_specialty Receptors Retinoic Acid medicine.medical_treatment Retinoic acid Tretinoin chemistry.chemical_compound Leukemia Promyelocytic Acute Internal medicine medicine Humans Child Chemotherapy business.industry All trans Complete remission Hematology medicine.disease Alternative treatment Surgery medicine.anatomical_structure chemistry Pediatrics Perinatology and Child Health Conventional chemotherapy Female Bone marrow business |
| Zdroj: | Pediatric Hematology and Oncology. 10:363-367 |
| ISSN: | 1521-0669 0888-0018 |
| DOI: | 10.3109/08880019309029517 |
| Popis: | A 12-year-old girl with acute promyelocytic leukemia has been treated with conventional chemotherapy. The patient remained in complete remission for a year when the first bone marrow relapse occurred. Since reinduction chemotherapy was rejected by the parents, an alternative treatment with oral all-trans retinoic acid was administered. A second complete remission was achieved within 100 days. After 14 months a second bone marrow relapse occurred. All-trans retinoic acid and the combination with interferon-alpha failed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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