Association between XRCC1 polymorphisms and glioma risk among Chinese population
| Autor: | Shang-Yuan Wang, Qiang Qu, Wei-Ming Luo, Jiang Li, Yong-Fu Wang, Jian Qu, Yu-Xia Xu, Qi-Shan Luo, You-Zhi He |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Genotype Biology Gastroenterology Pathogenesis XRCC1 Asian People Risk Factors Glioma Internal medicine medicine Humans Genetic Predisposition to Disease Allele Gene Hematology Polymorphism Genetic Brain Neoplasms Case-control study General Medicine Middle Aged medicine.disease DNA-Binding Proteins X-ray Repair Cross Complementing Protein 1 Oncology Case-Control Studies Cancer research Female |
| Zdroj: | Medical oncology (Northwood, London, England). 31(10) |
| ISSN: | 1559-131X |
| Popis: | The pathogenesis of glioma remains largely unknown now. It has been suggested that the X-ray cross-complementing group 1 (XRCC1) gene may influence the capacity to repair DNA damage leading to an increased gliomas susceptibility. This study aimed to evaluate the relationship between XRCC1 polymorphisms and glioma risk. Genotypes were assessed in 368 Chinese glioma patients and 346 healthy controls. XRCC1 Arg194Trp (rs1799782), Arg280His (rs25489) and Arg399Gln (rs25487) and three additional polymorphisms were directly sequenced. The frequency of Arg280His A allele was significant lower in glioma group than in healthy controls [9.6 vs 16%, OR=0.60 (0.46-0.80), P |
| Databáze: | OpenAIRE |
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