Reproducibility of coronary lumen, plaque, and vessel wall reconstruction and of endothelial shear stress measurements in vivo in humans
| Autor: | Richard E. Kuntz, Andreas Wahle, Milan Sonka, Peter Stone, Jeffrey J. Popma, Ahmet U. Coskun, Olusegun J. Ilegbusi, Yerem Yeghiazarians, Charles L. Feldman, Scott Kinlay, Maureen E. Clark |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Endothelium Lumen (anatomy) Blood Pressure Coronary Disease Coronary Angiography Restenosis Heart Rate In vivo Coronary Circulation Internal medicine Intravascular ultrasound medicine Humans Radiology Nuclear Medicine and imaging Triglycerides Ultrasonography Interventional Aged medicine.diagnostic_test Vascular disease business.industry Cholesterol HDL Reproducibility of Results Arteries Cholesterol LDL General Medicine Middle Aged Blood Viscosity medicine.disease Coronary Vessels Coronary arteries medicine.anatomical_structure Cardiology Endothelium Vascular Radiology Cardiology and Cardiovascular Medicine business Blood Flow Velocity Artery |
| Zdroj: | Catheterization and Cardiovascular Interventions. 60:67-78 |
| ISSN: | 1522-726X 1522-1946 |
| DOI: | 10.1002/ccd.10594 |
| Popis: | The purpose of this study was to assess the reproducibility of an in vivo methodology to reconstruct the lumen, plaque, and external elastic membrane (EEM) of coronary arteries and estimate endothelial shear stress (ESS). Ten coronary arteries without significant stenoses (five native and five stented arteries) were investigated. The 3D lumen and EEM boundaries of each coronary artery were determined by fusing end-diastolic intravascular ultrasound images with biplane coronary angiograms. Coronary flow was measured. Computational fluid dynamics was used to calculate local ESS. Complete data acquisition was then repeated. Analysis was performed on each data set in a blinded manner. The intertest correlation coefficients for all arteries for the two measurements of lumen radius, EEM radius, plaque thickness, and ESS were r = 0.96, 0.96, 0.94, 0.91, respectively (all P values < 0.0001). The 3D anatomy and ESS of human coronary arteries can be reproducibly estimated in vivo. This methodology provides a tool to examine the effect of ESS on atherogenesis, remodeling, and restenosis; the contribution of arterial remodeling and plaque growth to changes in the lumen; and the impact of new therapies. |
| Databáze: | OpenAIRE |
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