Physical activity reduces systemic blood pressure and improves early markers of atherosclerosis in pre-pubertal obese children
| Autor: | François Herrmann, Laetitia M. Marchand, Yacine Aggoun, Maurice Beghetti, Nathalie Farpour-Lambert, Xavier Martin |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Puberty/physiology Body Height/physiology physical activity 030204 cardiovascular system & hematology Oxygen Consumption/physiology Body Mass Index 0302 clinical medicine Body Fat Distribution 030212 general & internal medicine Biological Markers/blood Child Ultrasonography 2. Zero hunger Cholesterol HDL/blood ddc:618 Cross-Over Studies Exercise Tolerance Vasodilation/physiology Atherosclerosis/*blood/*physiopathology Endothelium Vascular/physiology/ultrasonography Exercise/*physiology VO2 max Tunica Intima/ultrasonography 3. Good health Carotid Artery Common/ultrasonography Vasodilation Hypertension Cardiology Tunica Media/ultrasonography Female Cardiology and Cardiovascular Medicine Tunica Media medicine.medical_specialty Carotid Artery Common Physical Fitness/physiology 03 medical and health sciences Insulin resistance Oxygen Consumption Internal medicine Exercise Tolerance/physiology medicine Aerobic exercise Humans Obesity Regional Blood Flow/physiology Exercise business.industry Body Weight Cholesterol HDL Puberty Cardiorespiratory fitness medicine.disease Atherosclerosis Crossover study Body Height Obesity/physiopathology/*therapy Blood pressure Endocrinology Body Weight/physiology Physical Fitness Regional Blood Flow ddc:618.97 Arterial stiffness Endothelium Vascular Insulin Resistance business Tunica Intima Insulin Resistance/physiology Body mass index Biomarkers Hypertension/physiopathology/*therapy |
| Zdroj: | Journal of the American College of Cardiology, Vol. 54, No 25 (2009) pp. 2396-2406 |
| ISSN: | 1558-3597 0735-1097 |
| Popis: | OBJECTIVES: The aim of this study was to determine the effects of physical activity on systemic blood pressure (BP) and early markers of atherosclerosis in pre-pubertal obese children. BACKGROUND: Hypertension and endothelial dysfunction are premature complications of obesity. METHODS: We performed a 3-month randomized controlled trial with a modified crossover design: 44 pre-pubertal obese children (age 8.9 + or - 1.5 years) were randomly assigned (1:1) to an exercise (n = 22) or a control group (n = 22). We recruited 22 lean children (age 8.5 + or - 1.5 years) for baseline comparison. The exercise group trained 60 min 3 times/week during 3 months, whereas control subjects remained relatively inactive. Then, both groups trained twice/week during 3 months. We assessed changes at 3 and 6 months in office and 24-h BP, arterial intima-media thickness (IMT) and stiffness, endothelial function (flow-mediated dilation), body mass index (BMI), body fat, cardiorespiratory fitness (maximal oxygen consumption [VO(2)max]), physical activity, and biological markers. RESULTS: Obese children had higher BP, arterial stiffness, body weight, BMI, abdominal fat, insulin resistance indexes, and C-reactive protein levels, and lower flow-mediated dilation, VO(2)max, physical activity, and high-density lipoprotein cholesterol levels than lean subjects. At 3 months, we observed significant changes in 24-h systolic BP (exercise -6.9 + or - 13.5 mm Hg vs. control 3.8 + or - 7.9 mm Hg, -0.8 + or - 1.5 standard deviation score [SDS] vs. 0.4 + or - 0.8 SDS), diastolic BP (-0.5 + or - 1.0 SDS vs. 0 + or - 1.4 SDS), hypertension rate (-12% vs. -1%), office BP, BMI z-score, abdominal fat, and VO(2)max. At 6 months, change differences in arterial stiffness and IMT were significant. CONCLUSIONS: A regular physical activity program reduces BP, arterial stiffness, and abdominal fat; increases cardiorespiratory fitness; and delays arterial wall remodeling in pre-pubertal obese children. (Effects of Aerobic Exercise Training on Arterial Function and Insulin Resistance Syndrome in Obese Children: A Randomized Controlled Trial; NCT00801645). |
| Databáze: | OpenAIRE |
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