Serum Apelin and Asymmetric Dimethylarginine Levels in Patients With Exfoliation Syndrome or Exfoliative Glaucoma
| Autor: | Zeliha Gunnur Dikmen, Figen Bezci Aygun, Anastasios G. P. Konstas, Mutlu Umaroğlu, Sibel Kocabeyoglu, Murat Irkec |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Systemic disease medicine.medical_specialty Enzyme-Linked Immunosorbent Assay Arginine Exfoliation Syndrome Slit Lamp Microscopy Coronary artery disease Tonometry Ocular 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Diabetes mellitus medicine Humans Prospective Studies Enzyme Inhibitors Prospective cohort study Intraocular Pressure Aged Aged 80 and over business.industry Middle Aged medicine.disease eye diseases Apelin Ophthalmoscopy Ophthalmology Cross-Sectional Studies Endocrinology chemistry 030221 ophthalmology & optometry Female Analysis of variance Asymmetric dimethylarginine business Body mass index Glaucoma Open-Angle 030217 neurology & neurosurgery |
| Zdroj: | Journal of Glaucoma. 29:593-597 |
| ISSN: | 1057-0829 |
| DOI: | 10.1097/ijg.0000000000001513 |
| Popis: | PReCIS:: Apelin and asymmetric dimethylarginine (ADMA) concentrations, affecting the nitric oxide pathway, were different in the patient group compared with the control subjects. These 2 molecules may have potential effects in vascular pathologies and their possible role in predisposition to vascular comorbidities in exfoliation syndrome (XFS) or exfoliative glaucoma (XFG). Purpose To evaluate apelin and ADMA levels in serum samples from patients with XFS or XFG compared with healthy control subjects. Methods Serum ADMA and apelin concentrations were evaluated from 36 and 32 XFS patients; 27 and 24 XFG patients; and 34 and 30 healthy controls, respectively. Subjects without systemic disease (including diabetes mellitus, hypertension, coronary artery disease, obesity) were included in the study and body mass index was calculated in all participants. An enzyme-linked immunosorbent assay and high-performance liquid chromatography were used to determine serum apelin and ADMA concentrations. Independent sample t test, χ test, analysis of variance test, and Pearson test were used for statistical analysis. Results Mean serum apelin levels of XFG, XFS, and control group were 1063.3±373.4, 1196.7±433.7, and 1343.3±405.1 ng/mL, respectively. Patients with XFG demonstrated significantly lower level of apelin versus controls (P=0.034). Mean serum ADMA concentration was significantly greater in XFS subjects (2.05±0.98 µmol/L) compared with normal controls (1.57±0.58 µmol/L) (P=0.042). No association was detected between ADMA and apelin concentrations and age, sex, and body mass index for both XFS and XFG groups. Conclusions Significant alterations in serum levels of apelin and ADMA may suggest potential effects in vascular pathologies and a possible role in predisposition to vascular comorbidities in XFS/XFG. |
| Databáze: | OpenAIRE |
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