Angiogenesis in the atherosclerotic plaque
| Autor: | Anne Nègre-Salvayre, Robert Salvayre, Mélanie Pucelle, Caroline Camaré |
|---|---|
| Přispěvatelé: | Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de médecine moléculaire de Rangueil (I2MR), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IFR150-Institut National de la Santé et de la Recherche Médicale (INSERM), Régulations cellulaires: lipidoses et atherosclerose, IFR 31 Louis Bugnard (IFR 31), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Toulouse [Toulouse]-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Toulouse [Toulouse]-Université Toulouse III - Paul Sabatier (UT3) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Apolipoprotein E
SMC smooth muscle cell nNOS neuronal nitric oxide synthase RTKs receptor tyrosine kinase Review Article Matrix metalloproteinase Fibroblast growth factor Biochemistry 0302 clinical medicine ERK extracellular signal-regulated kinase RCT reverse cholesterol transport Medicine lcsh:QH301-705.5 ComputingMilieux_MISCELLANEOUS ApoE apolipoprotein E ICAM-1 InterCellular Adhesion Molecule-1 Neovascularization Pathologic NADPH H+ nicotinamide adenine dinucleotide phosphate VCAM-1 Vascular Cell Adhesion Molecule-1 ABCG1 ATP-binding cassette sub-family G member 1 Plaque Atherosclerotic ECM extracellular matrix 3. Good health S1PR S1P receptors FAK focal adhesion kinase S1P sphingosine 1-phosphate iNOS inducible nitric oxide synthase Disease Progression lcsh:Medicine (General) ADMA assymetric methylarginine PI3K phosphoinositide 3 kinase Spns2 S1P carry spinster homolog 2 Hypercholesterolemia PHD prolyl hydroxylase 03 medical and health sciences TGF-β transforming growth factor-β PKC protein kinase C PUFA polyunsaturated fatty acid Humans FGF basic fibroblast growth factor NRP-1 neuropilin-1 EGF epidermal growth factor NO nitric oxide SRC Sarcoma tyrosine kinase Cholesterol TIMPs Tissue Inhibitor of Metalloproteinases Flt-1 fms-like tyrosine kinase-1 HDL high density lipopoprotein 030104 developmental biology chemistry NF-kB nuclear factor kappaB Immunology FGFR FGF receptor Angiogenesis PDGFR PDGF receptor 0301 basic medicine [SDV]Life Sciences [q-bio] AC adenylate cyclase Clinical Biochemistry Angiogenesis Inhibitors 030204 cardiovascular system & hematology PDGF platelet-derived growth factor LDLs low density lipoproteins TGFβR TGF-β receptor Neovascularization chemistry.chemical_compound HUVEC human umbilical vein endothelial cell ROCK Rho associated protein kinase LOX lipoxygenase nSMase2 neutral sphingomyelinase-2 APOE human ApoE gene Clinical Trials as Topic lcsh:R5-920 SK1 sphingosine kinase −1 eNOS endothelial nitric oxide synthase VEGF vascular endothelial growth factor VEGF MMP matrix metalloproteinase H2O2 hydrogen peroxide Dll4 Delta-like-4 EGFR EGF receptor medicine.symptom TLR Toll-like receptor Inflammation HIF Hypoxia inducible factor ARNT aryl hydrocarbon nuclear translocator PLC phospholipase C ROS reactive oxygen species Animals CPT1A carnitine palmityl transferase VCAM-1 PAI-1 plasminogen activator inhibitor 1 PPAR peroxisome proliferator activated receptor VEGFR VEGF receptor AIBP ApoA-I binding protein business.industry TK tyrosine kinase Organic Chemistry Apoe animal ApoE gene Atherosclerosis ApoE−/− mice homozygous ApoE-deficient mice HSP heparan sulfate proteoglycans COX cyclooxygenase Oxidative Stress lcsh:Biology (General) Cancer research business MAPK mitogen activated protein kinase |
| Zdroj: | Redox Biology Redox Biology, Elsevier, 2017, 12, pp.18-34. ⟨10.1016/j.redox.2017.01.007⟩ Redox Biology, Vol 12, Iss, Pp 18-34 (2017) |
| ISSN: | 2213-2317 |
| DOI: | 10.1016/j.redox.2017.01.007⟩ |
| Popis: | Atherosclerosis is a multifocal alteration of the vascular wall of medium and large arteries characterized by a local accumulation of cholesterol and non-resolving inflammation. Atherothrombotic complications are the leading cause of disability and mortality in western countries. Neovascularization in atherosclerotic lesions plays a major role in plaque growth and instability. The angiogenic process is mediated by classical angiogenic factors and by additional factors specific to atherosclerotic angiogenesis. In addition to its role in plaque progression, neovascularization may take part in plaque destabilization and thromboembolic events. Anti-angiogenic agents are effective to reduce atherosclerosis progression in various animal models. However, clinical trials with anti-angiogenic drugs, mainly anti-VEGF/VEGFR, used in anti-cancer therapy show cardiovascular adverse effects, and require additional investigations. Graphical abstract fx1 Highlights • Intimal neovascularization in plaque growth and destabilization. • Role of classical and specific angiogenic factors in atherosclerotic angiogenesis. • Inflammation and oxidative stress promote angiogenesis and plaque destabilization. • Angiogenesis promote intraplaque hemorrhages, afflux of blood cells and lipids. • Anti-angiogenic therapy for atherosclerotic angiogenesis. |
| Databáze: | OpenAIRE |
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