Activation response and functional connectivity change in rat cortex after bilateral transcranial direct current stimulation—An exploratory study

Autor: Dirk Jan Ardesch, Caroline L. van Heijningen, Willem M. Otte, Annette van der Toorn, Milou Straathof, Gerard van Vliet, Julia Boonzaier, Rick M. Dijkhuizen
Přispěvatelé: Adult Psychiatry, Complex Trait Genetics, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Amsterdam Neuroscience - Complex Trait Genetics
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Male
Cerebral Cortex/physiology
medicine.medical_treatment
resting-state functional connectivity
Stimulation
Magnetic Resonance Imaging/methods
Rats
Sprague-Dawley
Sensorimotor Cortex/blood supply
03 medical and health sciences
Cellular and Molecular Neuroscience
models
0302 clinical medicine
SDG 3 - Good Health and Well-being
medicine
Premovement neuronal activity
Animals
magnetic resonance imaging
animal
Research Articles
Transcranial Direct Current Stimulation/methods
Cerebral Cortex
Transcranial direct-current stimulation
medicine.diagnostic_test
business.industry
Nerve Net/blood supply
resting‐state functional connectivity
Magnetic resonance imaging
Neuromodulation (medicine)
Rats
030104 developmental biology
Cerebral blood flow
Brain stimulation
Sensorimotor Cortex
Sprague-Dawley
Nerve Net
transcranial direct current stimulation
Motor learning
business
Neuroscience
030217 neurology & neurosurgery
Research Article
Zdroj: Boonzaier, J, Straathof, M, Ardesch, D J, van der Toorn, A, van Vliet, G, van Heijningen, C L, Otte, W M & Dijkhuizen, R M 2021, ' Activation response and functional connectivity change in rat cortex after bilateral transcranial direct current stimulation—An exploratory study ', Journal of Neuroscience Research, vol. 99, no. 5, pp. 1377-1389 . https://doi.org/10.1002/jnr.24793
Journal of neuroscience research, 99(5), 1377-1389. Wiley-Liss Inc.
Journal of Neuroscience Research, 99(5), 1377-1389. Wiley-Liss Inc.
Journal of Neuroscience Research
ISSN: 0360-4012
DOI: 10.1002/jnr.24793
Popis: Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique implicated as a promising adjunct therapy to improve motor function through the neuromodulation of brain networks. Particularly bilateral tDCS, which affects both hemispheres, may yield stronger effects on motor learning than unilateral stimulation. Therefore, the aim of this exploratory study was to develop an experimental model for simultaneous magnetic resonance imaging (MRI) and bilateral tDCS in rats, to measure instant and resultant effects of tDCS on network activity and connectivity. Naïve, male Sprague‐Dawley rats were divided into a tDCS (n = 7) and sham stimulation group (n = 6). Functional MRI data were collected during concurrent bilateral tDCS over the sensorimotor cortex, while resting‐state functional MRI and perfusion MRI were acquired directly before and after stimulation. Bilateral tDCS induced a hemodynamic activation response, reflected by a bilateral increase in blood oxygenation level‐dependent signal in different cortical areas, including the sensorimotor regions. Resting‐state functional connectivity within the cortical sensorimotor network decreased after a first stimulation session but increased after a second session, suggesting an interaction between multiple tDCS sessions. Perfusion MRI revealed no significant changes in cerebral blood flow after tDCS. Our exploratory study demonstrates successful application of an MRI‐compatible bilateral tDCS setup in an animal model. Our results indicate that bilateral tDCS can locally modulate neuronal activity and connectivity, which may underlie its therapeutic potential.
Our study demonstrates that simultaneous functional magnetic resonance imaging (MRI) and transcranial direct current stimulation (tDCS) in rats is feasible with an MRI‐compatible electrode montage. We found that bilateral tDCS can locally modulate neural activity and functional connectivity in rat brain, while cortical functional connectivity is differentially affected under the tDCS cathode and anode.
Databáze: OpenAIRE
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