Alpha-1 Antitrypsin Deficiency and Tobacco Smoking: Exploring Risk Factors and Smoking Cessation in a Registry Population

Autor:	Hamad Alkandari, Andrew Woodsmith, Mansour A. Alkhunaizi, Tomás P. Carroll, Layali Aldaihani, Siobhán E Lee, Alessandro N Franciosi, Laura T Fee, Noel G. McElvaney
Rok vydání:	2021
Předmět:	Pulmonary and Respiratory Medicine medicine.medical_specialty Genotype medicine.medical_treatment Population 03 medical and health sciences Pulmonary Disease Chronic Obstructive 0302 clinical medicine Risk Factors Internal medicine alpha 1-Antitrypsin Deficiency Tobacco Smoking Medicine Humans 030212 general & internal medicine Registries education education.field_of_study COPD Alpha 1-antitrypsin deficiency business.industry medicine.disease respiratory tract diseases 030228 respiratory system alpha 1-Antitrypsin Smoking cessation Smoking Cessation Health behavior business
Zdroj:	COPD. 18(1)
ISSN:	1541-2563
Popis:	The ZZ genotype of alpha-1 antitrypsin deficiency (AATD) is strongly associated with COPD, even in never-smokers. Moderate AATD genotypes (MZ and SZ) have been shown to increase the severity of COPD in smokers. In this comparative study, we examine the association between AATD, genotypes, and smoking cessation. Two hundred and ninety-three Irish people with AATD [MZ (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d623c40538ad5b395ecf756e5ad0bcd7 https://pubmed.ncbi.nlm.nih.gov/33557645 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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