Deep Learning for Automated Measurement of Hemorrhage and Perihematomal Edema in Supratentorial Intracerebral Hemorrhage
| Autor: | Rommell B Noche, Ali Hamzehloo, Andres Ruiz, Guido J. Falcone, Kevin N. Sheth, Yasheng Chen, Elayna Kirsch, Chia-Ling Phuah, Daniel Woo, Julian N Acosta, Thomas M. Gill, Jin-Moo Lee, Rajat Dhar, Kilian Roth |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Concordance Brain Edema 030204 cardiovascular system & hematology Article Cohort Studies 03 medical and health sciences Deep Learning 0302 clinical medicine Interquartile range Edema Humans Medicine Perihematomal edema Spontaneous intracerebral hemorrhage Cerebral Hemorrhage Advanced and Specialized Nursing Intracerebral hemorrhage Hematoma business.industry External validation Middle Aged medicine.disease Imaging algorithm Biomarker (medicine) Female Neurology (clinical) Cardiology and Cardiovascular Medicine business Nuclear medicine Algorithms 030217 neurology & neurosurgery |
| Zdroj: | Stroke |
| ISSN: | 1524-4628 0039-2499 |
| DOI: | 10.1161/strokeaha.119.027657 |
| Popis: | Background and Purpose— Volumes of hemorrhage and perihematomal edema (PHE) are well-established biomarkers of primary and secondary injury, respectively, in spontaneous intracerebral hemorrhage. An automated imaging pipeline capable of accurately and rapidly quantifying these biomarkers would facilitate large cohort studies evaluating underlying mechanisms of injury. Methods— Regions of hemorrhage and PHE were manually delineated on computed tomography scans of patients enrolled in 2 intracerebral hemorrhage studies. Manual ground-truth masks from the first cohort were used to train a fully convolutional neural network to segment images into hemorrhage and PHE. The primary outcome was automated-versus-human concordance in hemorrhage and PHE volumes. The secondary outcome was voxel-by-voxel overlap of segmentations, quantified by the Dice similarity coefficient (DSC). Algorithm performance was validated on 84 scans from the second study. Results— Two hundred twenty-four scans from 124 patients with supratentorial intracerebral hemorrhage were used for algorithm derivation. Median volumes were 18 mL (interquartile range, 8–43) for hemorrhage and 12 mL (interquartile range, 5–30) for PHE. Concordance was excellent (0.96) for automated quantification of hemorrhage and good (0.81) for PHE, with DSC of 0.90 (interquartile range, 0.85–0.93) and 0.54 (0.39–0.65), respectively. External validation confirmed algorithm accuracy for hemorrhage (concordance 0.98, DSC 0.90) and PHE (concordance 0.90, DSC 0.55). This was comparable with the consistency observed between 2 human raters (DSC 0.90 for hemorrhage, 0.57 for PHE). Conclusions— We have developed a deep learning-based imaging algorithm capable of accurately measuring hemorrhage and PHE volumes. Rapid and consistent automated biomarker quantification may accelerate powerful and precise studies of disease biology in large cohorts of intracerebral hemorrhage patients. |
| Databáze: | OpenAIRE |
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