Itraconazole in the treatment of basal cell carcinoma: A case‐based review of the literature

Autor:	Ken Hiu-Kan Ip, Kevin McKerrow
Rok vydání:	2021
Předmět:	Drug Skin Neoplasms Itraconazole media_common.quotation_subject Administration Oral Antineoplastic Agents Dermatology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Humans Medicine Itraconazole 100 MG Basal cell carcinoma Basal cell media_common business.industry medicine.disease Hedgehog signalling Treatment Outcome Carcinoma Basal Cell 030220 oncology & carcinogenesis Cancer research business Signal Transduction medicine.drug
Zdroj:	Australasian Journal of Dermatology. 62:394-397
ISSN:	1440-0960 0004-8380
DOI:	10.1111/ajd.13655
Popis:	Itraconazole is as an anti-fungal agent with the ability to inhibit the Hedgehog signalling pathway, which makes it a candidate drug that can be repurposed for the treatment of basal cell carcinomas (BCCs). We present a case of metastatic BCC, treated with oral itraconazole 100 mg twice daily, that resulted in sustained partial regression of metastatic pulmonary nodules. A systematic review on the clinical outcomes of BCCs treated with itraconazole highlights that current evidence for its clinical application remains limited and that this is the first case report where itraconazole monotherapy has achieved favourable response in metastatic BCC.
Databáze:	OpenAIRE
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