Molecular and Epigenetic Mechanisms for the Complex Effects of Stress on Synaptic Physiology and Cognitive Functions
| Autor: | Zhen Yan, Eunice Y. Yuen, Jing Wei |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
cognition Glutamic Acid emotion AMPA receptor Review Biology Neurotransmission Synaptic Transmission Epigenesis Genetic 03 medical and health sciences Glutamatergic stress protein ubiquitination 0302 clinical medicine Postsynaptic potential trafficking glucocorticoid receptor Animals Humans Pharmacology (medical) Chronic stress Prefrontal cortex E3 ligase Pharmacology prefrontal cortex Glutamate receptor glutamatergic transmission NMDA receptor stress-related mental disorders Psychiatry and Mental health 030104 developmental biology Synapses histone deacetylase Cognition Disorders Neuroscience corticosterone stress hormones 030217 neurology & neurosurgery Stress Psychological |
| Zdroj: | International Journal of Neuropsychopharmacology |
| ISSN: | 1469-5111 |
| Popis: | Evidence over the past decades has found that stress, particularly through the corticosterone stress hormones, produces complex changes in glutamatergic signaling in prefrontal cortex, which leads to the alteration of cognitive processes medicated by this brain region. Interestingly, the effects of stress on glutamatergic transmission appear to be “U-shaped,” depending upon the duration and severity of the stressor. These biphasic effects of acute vs chronic stress represent the adaptive vs maladaptive responses to stressful stimuli. Animal studies suggest that the stress-induced modulation of excitatory synaptic transmission involves changes in presynaptic glutamate release, postsynaptic glutamate receptor membrane trafficking and degradation, spine structure and cytoskeleton network, and epigenetic control of gene expression. This review will discuss current findings on the key molecules involved in the stress-induced regulation of prefrontal cortex synaptic physiology and prefrontal cortex-mediated functions. Understanding the molecular and epigenetic mechanisms that underlie the complex effects of stress will help to develop novel strategies to cope with stress-related mental disorders. |
| Databáze: | OpenAIRE |
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