Investigation into Possible Association of Oxandrolone and Heterotopic Ossification Following Burn Injury
| Autor: | Benjamin Levi, Kaetlin Vasquez, Colleen M. Ryan, Michael Sorkin, Jeffrey C. Schneider, Serra Ucer Ozgurel, Anita Vaishampayan, Catherine R Thorpe, Charles Hwang, Richard Goldstein, Robert L. Sheridan, Jonathan S. Friedstat, Gabrielle G Grant, Jeremy Goverman, Chase A. Pagani, Laura C. Simko, John T. Schulz |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Burn injury medicine.medical_treatment Tenotomy Oxandrolone 030207 dermatology & venereal diseases 03 medical and health sciences Mice 0302 clinical medicine Anabolic Agents 2019 Annual Meeting Abstract/Poster Risk Factors Statistical significance medicine Animals Humans Risk factor Wound Healing Framingham Risk Score business.industry Ossification Heterotopic Rehabilitation 030208 emergency & critical care medicine Burn center medicine.disease Treatment Outcome Anesthesia Models Animal Emergency Medicine Surgery Heterotopic ossification Female business Burns medicine.drug |
| Zdroj: | J Burn Care Res |
| ISSN: | 1559-0488 |
| Popis: | Oxandrolone, a testosterone analog, is used to counteract the catabolic effects of burn injury. Recent animal studies suggest a possible hormonal association with heterotopic ossification (HO) development postburn. This work examines oxandrolone administration and HO development by exploring historical clinical data bridging the introduction of oxandrolone into clinical practice. Additionally, we examine associations between oxandrolone administration and HO in a standardized mouse model of burn/trauma-related HO. Acutely burned adults admitted between 2000 and 2014, survived through discharge, and had a HO risk factor of 7 or higher were selected for analysis from a single burn center. Oxandrolone administration, clinical and demographic data, and elbow HO were recorded and were analyzed with logistic regression. Associations of oxandrolone with HO were examined in a mouse model. Mice were administered oxandrolone or vehicle control following burn/tenotomy to examine any potential effect of oxandrolone on HO and were analyzed by Student's t test. Subjects who received oxandrolone had a higher incidence of elbow HO than those that did not receive oxandrolone. However, when controlling for oxandrolone administration, oxandrolone duration, postburn day oxandrolone initiation, HO risk score category, age, sex, race, burn size, and year of injury, there was no significant difference between rates of elbow HO between the two populations. In agreement with the review, in the mouse model, while there was a trend toward the oxandrolone group developing a greater volume of HO, this did not reach statistical significance. |
| Databáze: | OpenAIRE |
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