Increased soluble CD36 is linked to advanced steatosis in nonalcoholic fatty liver disease
| Autor: | José Luís Porrero, Enrique Chávez-Jiménez, María E. Miquilena-Colina, Javier Vargas-Castrillón, A. Díaz, Javier Rodríguez de Cía, Agustín Domínguez-Díez, Antonio Madejón, Javier García-Samaniego, Alicia Saez, Susana Soto-Fernández, Carmelo García-Monzón, Oreste Lo Iacono, Miguel Fernández-Bermejo, Manuel Romero-Gómez, Rocío Gallego-Durán, Javier Crespo |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
CD36 Antigens Male medicine.medical_specialty CD36 Clinical Biochemistry Biochemistry Severity of Illness Index Insulin resistance Non-alcoholic Fatty Liver Disease Risk Factors Internal medicine Nonalcoholic fatty liver disease medicine Humans biology business.industry General Medicine Odds ratio Hepatitis C Chronic Middle Aged medicine.disease Confidence interval Fatty Liver Endocrinology Liver Case-Control Studies biology.protein Immunohistochemistry Female Steatohepatitis Steatosis business |
| Zdroj: | European journal of clinical investigation. 44(1) |
| ISSN: | 1365-2362 |
| Popis: | Background Soluble CD36 (sCD36) clusters with insulin resistance, but no evidence exists on its relationship with hepatic fat content. We determined sCD36 to assess its link to steatosis in nonalcoholic fatty liver disease (NAFLD) and chronic hepatitis C (CHC) patients. Materials and methods Two hundred and twenty-seven NAFLD, eighty-seven CHC, and eighty-five patients with histologically normal liver (NL) were studied. Steatosis was graded by Kleiner's histological scoring system. Serum sCD36 and hepatic CD36 expression was assessed by immunoassay and immunohistochemistry, respectively. Results In NAFLD, serum sCD36 levels were significantly higher in simple steatosis than in NL (361·4 ± 286·4 vs. 173·9 ± 137·4 pg/mL, respectively; P |
| Databáze: | OpenAIRE |
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