HIV infection and placental malaria reduce maternal transfer of multiple antimalarial antibodies in Mozambican women

Autor: Marta Vidal, David R. Cavanagh, M. Nelia Manaca, Raquel González, Esperança Sevene, Pau Cisteró, Chenjerai Jairoce, María Rupérez, John J. Aponte, Benoit Gamain, Evelina Angov, Carlota Dobaño, Arsenio Nhacolo, Reyes Balcells, James G. Beeson, Eusebio Macete, Miquel Vázquez-Santiago, Anifa Vala, Selena Alonso, Gemma Moncunill, Alfredo Mayor, Laura Fuente-Soro, Clara Menéndez, Ross L. Coppel, Ruth Aguilar, Gemma Ruiz-Olalla
Přispěvatelé: Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Centro de Investigação em Saúde de Manhiça [Maputo, Mozambique] (CISM), Walter Reed Army Institute of Research, Monash University [Melbourne], Biologie Intégrée du Globule Rouge (BIGR (UMR_S_1134 / U1134)), Institut National de la Transfusion Sanguine [Paris] (INTS)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Université des Antilles (UA)-Université de Paris (UP), University of Edinburgh, Burnet Institute [Melbourne, Victoria], Eduardo Mondlane University, Gamain, Benoit, Institut National de la Transfusion Sanguine [Paris] (INTS)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Université des Antilles (UA)-Université Paris Cité (UPCité)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
cord blood antibodies
[SDV]Life Sciences [q-bio]
Cord blood antibodies
Antibodies
Protozoan
HIV Infections
placental malaria
0302 clinical medicine
Placental malaria
Pregnancy
030212 general & internal medicine
Malaria
Falciparum
Child
[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology
biology
3. Good health
[SDV] Life Sciences [q-bio]
Infectious Diseases
[SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology
[SDV.IMM.IA] Life Sciences [q-bio]/Immunology/Adaptive immunology
Cord blood
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
[SDV.IMM]Life Sciences [q-bio]/Immunology
Female
Antibody
[SDV.MP.PAR] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology
Microbiology (medical)
Cord
[SDV.IMM] Life Sciences [q-bio]/Immunology
IgG
Plasmodium falciparum
030106 microbiology
Antimalarials
03 medical and health sciences
Placental transfer
Antigen
parasitic diseases
medicine
Humans
[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology
IgG subclasses
Maternal antibodies
business.industry
Infant
Transplacental
HIV
medicine.disease
biology.organism_classification
Malaria
placental transfer
maternal antibodies
Immunology
biology.protein
business
Zdroj: Alonso, S, Vidal, M, Ruiz-Olalla, G, González, R, Jairoce, C, Manaca, M N, Vázquez-Santiago, M, Balcells, R, Vala, A, Ruperez, M, Cisteró, P, Fuente-Soro, L, Angov, E, Coppel, R L, Gamain, B, Cavanagh, D, Beeson, J G, Nhacolo, A, Sevene, E, Aponte, J J, Macete, E, Aguilar, R, Mayor, A, Menéndez, C, Dobaño, C & Moncunill, G 2021, ' HIV infection and placental malaria reduce maternal transfer of multiple antimalarial antibodies in Mozambican women ', Journal of Infection, vol. 82, no. 4, pp. 45-57 . https://doi.org/10.1016/j.jinf.2021.02.024
Journal of Infection
Journal of Infection, WB Saunders, 2021, 82 (4), pp.45-57. ⟨10.1016/j.jinf.2021.02.024⟩
JOURNAL OF INFECTION
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Universitat Politècnica de Catalunya (UPC)
ISSN: 0163-4453
Popis: Objectives: Maternal Plasmodium falciparum-specific antibodies may contribute to protect infants against severe malaria. Our main objective was to evaluate the impact of maternal HIV infection and placental malaria on the cord blood levels and efficiency of placental transfer of IgG and IgG subclasses. Methods: In a cohort of 341 delivering HIV-negative and HIV-positive mothers from southern Mozambique, we measured total IgG and IgG subclasses in maternal and cord blood pairs by quantitative suspension array technology against eight P. falciparum antigens: Duffy-binding like domains 3-4 of VAR2CSA from the erythrocyte membrane protein 1, erythrocyte-binding antigen 140, exported protein 1 (EXP1), merozoite surface proteins 1, 2 and 5, and reticulocyte-binding-homologue-4.2 (Rh4.2). We performed univariable and multivariable regression models to assess the association of maternal HIV infection, placental malaria, maternal variables and pregnancy outcomes on cord antibody levels and antibody transplacental transfer. Results: Maternal antibody levels were the main determinants of cord antibody levels. HIV infection and placental malaria reduced the transfer and cord levels of IgG and IgG1, and this was antigen-dependent. Low birth weight was associated with an increase of IgG2 in cord against EXP1 and Rh4.2. Conclusions: We found lower maternally transferred antibodies in HIV-exposed infants and those born from mothers with placental malaria, which may underlie increased susceptibility to malaria in these children. (C) 2021 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
Databáze: OpenAIRE
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