Neuroinflammation in Parkinson's patients and MPTP-treated mice is not restricted to the nigrostriatal system:microgliosis and differential expression of interleukin-1 receptors in the olfactory bulb
| Autor: | Patrick Cras, John J. P. Brevé, Jane K. Relton, Anne Marie Van Dam, John G.J.M. Bol, Piet V.J.M. Hoogland, Anne Vroon, Stuart M. Allan, Benjamin Drukarch |
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| Přispěvatelé: | Anatomy and neurosciences |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Male
Aging Parkinson's disease Gene Expression Substantia nigra Striatum Biology Microgliosis Biochemistry Mice chemistry.chemical_compound Endocrinology Parkinsonian Disorders Genetics medicine Animals Humans Molecular Biology Neuroinflammation DNA Primers Base Sequence MPTP MPTP Poisoning Receptors Interleukin-1 Parkinson Disease Cell Biology Anatomy medicine.disease Olfactory Bulb Corpus Striatum Olfactory bulb Mice Inbred C57BL Substantia Nigra chemistry nervous system Human medicine Microglia Neuroscience |
| Zdroj: | Vroon, A, Drukarch, B, Bol, J G J M, Cras, P, Brevé, J J P, Allan, S M, Relton, J K, Hoogland, P V J M & Van Dam, A-M 2007, ' Neuroinflammation in Parkinson's patients and MPTP-treated mice is not restricted to the nigrostriatal system : microgliosis and differential expression of interleukin-1 receptors in the olfactory bulb ', Experimental Gerontology, vol. 42, no. 8, pp. 762-71 . https://doi.org/10.1016/j.exger.2007.04.010 Experimental Gerontology, 42(8), 762-71. Elsevier Inc. Experimental gerontology |
| ISSN: | 0531-5565 |
| Popis: | Neuroinflammation may play a role in the pathogenesis of Parkinson's disease (PD). The present study questioned whether this neuroinflammatory response differs between the olfactory bulb, as an early affected region and the nigrostriatal system. Indeed, increased microgliosis was shown in post-mortem olfactory bulb of PD patients. Also in olfactory bulb of MPTP-treated mice, microgliosis and increased expression of IL-1 alpha, IL-1 beta and IL-1ra mRNA was observed early after treatment. These observations implicate that neuroinflammation is not restricted to the nigrostriatal system. MPTP-induced microgliosis in striatum and olfactory bulb was reduced in IL-1 alpha/beta knockout mice, indicating that IL-1 affects microglia activation. Importantly, MPTP induced differential regulation of IL-1 receptors. mRNA levels of IL-IRI and, to a lesser extent, IL-IRII were increased in striatum. Interestingly, in the olfactory bulb only IL-IRII mRNA was enhanced. We suggest that differential regulation of IL-1 signaling can serve as an important mechanism to modulate neuroinflammatory activity after MPTP treatment and possibly during PD. (c) 2007 Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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