PSMA PET/CT vs. CT alone in newly diagnosed biochemical recurrence of prostate cancer after radical prostatectomy: Comparison of detection rates and therapeutic implications
| Autor: | Christina Antke, Lino M Sawicki, Janna Morawitz, Christian Arsov, Eduards Mamlins, J Lakes, Joel Aissa, Christina Loberg, Peter Albers, Lars Schimmöller, Gerald Antoch, Nils-Martin Bruckmann, Julian Kirchner, Andreas Hiester |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Biochemical recurrence medicine.medical_specialty medicine.medical_treatment urologic and male genital diseases 030218 nuclear medicine & medical imaging Lesion 03 medical and health sciences Prostate cancer 0302 clinical medicine Recurrence Positron Emission Tomography Computed Tomography medicine Glutamate carboxypeptidase II Humans Radiology Nuclear Medicine and imaging Retrospective Studies Prostatectomy medicine.diagnostic_test business.industry Prostatic Neoplasms Retrospective cohort study General Medicine Prostate-Specific Antigen medicine.disease Positron emission tomography 030220 oncology & carcinogenesis Histopathology Neoplasm Recurrence Local medicine.symptom Tomography X-Ray Computed Nuclear medicine business |
| Zdroj: | European Journal of Radiology. 136:109556 |
| ISSN: | 0720-048X |
| Popis: | Objectives To compare prostate specific membrane antigen (PSMA) Positron Emission Tomography/Computed Tomography (PET/CT) and computed tomography (CT) alone for the detection of biochemical recurrence of prostate cancer (PCa) and effect on treatment. Methods This retrospective study included 59 patients with recently recorded biochemical recurrence of PCa (mean PSA 1.96 ± 1.64 ng/mL) after radical prostatectomy. Patients received PET/CT with either 68Ga-PSMA-11 (n = 36) or 18F-PSMA-1007 (n = 23). PET/CT and CT images were evaluated separately in regard to PCa lesion count, type, and localisation by two physicians. Histopathology, follow-up imaging and PSA levels after salvage irradiation served as reference standard. A McNemar test was used to compare detection rates. Changes in therapeutic approaches based on staging differences between CT alone and PET/CT were assessed in a virtual multidisciplinary tumour board. Results There were 142 lesions in 50 of 59 patients. PSMA PET/CT detected 141 lesions (99.3 %) in 50 patients (84.7 %), while CT detected 72 lesions (50.7 %) in 29 patients (49.2 %). A significantly higher detection rate of PSMA PET/CT was observed on a lesion-based analysis (p Conclusion PSMA PET/CT is superior to CT alone in detecting biochemical recurrence in PCa patients after radical prostatectomy and offered additional therapeutic options in a substantial number of patients. |
| Databáze: | OpenAIRE |
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