Survival estimates in European cystic fibrosis patients and the impact of socioeconomic factors: a retrospective registry cohort study
| Autor: | Edward F, McKone, Cono, Ariti, Abaigeal, Jackson, Anna, Zolin, Siobhán B, Carr, Annalisa, Orenti, Jacqui G, van Rens, Lydie, Lemonnier, Milan, Macek, Ruth H, Keogh, Lutz, Naehrlich, O, Turcu |
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| Přispěvatelé: | University of Zurich, McKone, Edward F |
| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Patient registry Cystic Fibrosis business.industry Proportional hazards model Confounding 610 Medicine & health Middle Aged medicine.disease Cystic fibrosis Cohort Studies Socioeconomic Factors 10036 Medical Clinic 2740 Pulmonary and Respiratory Medicine Internal medicine Genotype Medicine Humans Registries business Socioeconomic status Survival analysis Cohort study Retrospective Studies |
| Zdroj: | The European respiratory journal. 58(3) |
| ISSN: | 1399-3003 0903-1936 |
| Popis: | BackgroundMedian survival for cystic fibrosis (CF) patients in Europe is unknown and is likely to be influenced by socioeconomic factors. Using the European CF Society Patient Registry (ECFSPR), median survival estimates were obtained for CF patients across Europe and the impact of socioeconomic status on survival was examined.MethodsCF subjects known to be alive and in the ECFSPR between 2010 and 2014 were included. Survival curves were estimated using the Kaplan–Meier method. Differences in the survival curves were assessed using the log-rank test. Cox regression was used to estimate the association between socioeconomic factors and the age-specific hazard of death, with adjustment for sex, age at diagnosis, CF transmembrane conductance regulator (CFTR) genotype and transplant status.ResultsThe final analysis included 13 countries with 31 987 subjects (135 833 person-years of follow-up) and 1435 deaths. Median survival age for these patients in the ECFSPR was 51.7 (95% CI 50.0–53.4) years. After adjusting for potential confounders age at diagnosis, sex, CFTR genotype and transplant status, there remained strong evidence of an association between socioeconomic factors and mortality (pConclusionsMedian survival for patients with CF in Europe is comparable to that reported in other jurisdictions and differs by socioeconomic factors. |
| Databáze: | OpenAIRE |
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