Emergence of the Stem Cell Secretome in Regenerative Engineering
| Autor: | Nikoo Saveh-Shemshaki, Cato T. Laurencin, Kevin W.-H. Lo, Maumita Bhattacharjee, Leila Daneshmandi, Deandra Momah, Tahereh Jafari, Shiv Shah |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Wound Healing Tissue Engineering Stem Cells Cell- and Tissue-Based Therapy Bioengineering 02 engineering and technology Computational biology Biology 021001 nanoscience & nanotechnology Regenerative Medicine Article 03 medical and health sciences 030104 developmental biology Tissue engineering Conditioned medium Stem cell 0210 nano-technology Organ regeneration Biotechnology |
| Zdroj: | Trends Biotechnol |
| ISSN: | 1879-3096 |
| Popis: | The secretome is defined as the set of molecules and biological factors that are secreted by cells into the extracellular space. In the past decade, secretome-based therapies have emerged as a promising approach to overcome the limitations associated with cell-based therapies for tissue and organ regeneration. Considering the growing number of recent publications related to secretome-based therapies, this review takes a step-by-step engineering approach to evaluate the role of the stem cell secretome in regenerative engineering. We discuss the functional benefits of the secretome, the techniques used to engineer the secretome and tailor its therapeutic effects, and the delivery systems and strategies that have been developed to use the secretome for tissue regeneration. |
| Databáze: | OpenAIRE |
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