Facile Synthesis of Dihydroquinolines via Palladium Catalyzed Sequential Amination and Cyclisation of Morita‐Baylis‐Hillman Alcohols

Autor:	Saithalavi Anas, Pambingal Rajan Sruthi, Thachora Venu Saranya, P. Uma Sankar
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Allylic rearrangement Morita-Baylis-Hillman Communication Quinoline chemistry.chemical_element General Chemistry Allylicamination Communications Catalysis chemistry.chemical_compound chemistry Tosyl Cyclization Yield (chemistry) Intramolecular force Organic chemistry Organic & Supramolecular Chemistry Amination Palladium
Zdroj:	Chemistryselect
ISSN:	2365-6549
Popis:	Quinolines and its derivatives are significant class of heterocyclic compounds which are identified as the key component in many natural products and biologically important molecules. We describe herein a facile method for the synthesis of quinoline derivatives from Morita‐Baylis‐Hillman (MBH) Alcohols via Palladium Catalyzed intramolecular aryl amination followed by allylic amination pathway. The reaction between a series of MBH alcohols and amino compounds (Tosyl, aliphatic and aromatic amines) under optimized reaction conditions with Pd(PPh3)2Cl2/DPPP catalyst system, afforded the corresponding 1,2‐dihydroquinolines upto 95 % isolated yield. A facile method for the synthesis of 1, 2‐dihydroquinolines from Morita‐Baylis‐Hillman Alcohols via Palladium Catalyzed Intermolecular aryl amination followed by Intramolecular Allylic amination is described. The reaction of MBH alcohols with amino compounds under optimized conditions with Pd(PPh3)2Cl2/DPPP catalytic system produced corresponding dihydroquinolines upto 95 % yield.
Databáze:	OpenAIRE
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