Serum Interleukin-35 Level in Correlation with T Regulatory and T helper-17 Cells Frequency in Chronic Viral Hepatitis C Patients
| Autor: | Ossama A. Ahmed, Sherine E. Bendary, Dina M. Erfan, Amira E. Abdelhamid, Heba Ismail Aly, Safaa S. Abo-Elnour |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
business.industry t helper 17 cells t regulatory cells Applied Microbiology and Biotechnology Microbiology QR1-502 Correlation chc 03 medical and health sciences 030104 developmental biology 0302 clinical medicine immunosuppressive cytokines Immunology Interleukin 35 hcv Medicine interleukin 35 030211 gastroenterology & hepatology Chronic viral hepatitis C business Biotechnology |
| Zdroj: | Journal of Pure and Applied Microbiology, Vol 14, Iss 4, Pp 2431-2442 (2020) |
| ISSN: | 0973-7510 |
| Popis: | Interleukin-35 (IL-35), secreted mainly by T-regulatory cells (T-regs), has been considered to have immunosuppressive actions in many auto-immune diseases and tumors. However, information about its role in chronic hepatitis C (CHC) infection is still limited. We aimed to study the role of IL-35 within CHC infection and to assess its correlation with T-regs and T-helper 17 cells (Th-17). Therefore, we measured serum IL-35 concentrations using ELISA assay in 25 normal controls (NCs) and in 30 CHC patients before receiving direct antiviral agents (DAA) treatment and after 3 months of treatment end. T-regs and Th-17 cells frequencies were assessed via flow-cytometry in control group and patients’ group before treatment. The results showed that serum IL-35 levels revealed a highly significant increase in CHC patients compared to NCs (P |
| Databáze: | OpenAIRE |
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