Targeting Phthalocyanines to Tumor Cells Using Epidermal Growth Factor Conjugates
| Autor: | M.P. Kirpichnikov, E.A. Lukyanets, N.B. Feldman, G.V. Finakova, K.G. Skryabin, Sergey V. Lutsenko, G.N. Vorozhtsov, G.A. Posypanova, S.E. Severin |
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| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Indoles medicine.medical_treatment Melanoma Experimental Antineoplastic Agents Mice chemistry.chemical_compound In vivo Epidermal growth factor Internal medicine Organometallic Compounds Tumor Cells Cultured Animals Humans Medicine Cytotoxic T cell Cytotoxicity Epidermal Growth Factor business.industry Growth factor General Medicine Molecular biology In vitro Mice Inbred C57BL Endocrinology chemistry Phthalocyanine business hormones hormone substitutes and hormone antagonists Conjugate |
| Zdroj: | Tumor Biology. 20:218-224 |
| ISSN: | 1423-0380 1010-4283 |
| DOI: | 10.1159/000030066 |
| Popis: | Epidermal growth factor (EGF) was used as a vector for targeted delivery of phthalocyanines to tumor cells. The conjugates of EGF with disulfochloride aluminum phthalocyanine [Pc(Al)] and disulfochloride cobalt phthalocyanine [Pc(Co)] were synthesized. The cytotoxic activity of the conjugates against the human breast carcinoma cell line MCF-7 was determined. The cytotoxic activity of the EGF-Pc(Co) conjugate was 4.5 times higher than that of the EGF-Pc(Al) conjugate. The antitumor activity of the EGF-Pc(Co) conjugate was also studied in vivo in murine melanoma B16. Compared to free Pc(Co), intravenous injections of Pc(Co) conjugated with EGF inhibited tumor development and increased mean life span and mean survival time of experimental animals. |
| Databáze: | OpenAIRE |
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