Interleukin 10-Mediated Response and Correlated Anemia in a Patient with Advanced Non-Small Cell Lung Carcinoma
| Autor: | Christine S Cassidy, Jesse D Kelso, John Nemunaitis, F. Charles Brunicardi, Mushtaq Ashraf, Joseph R Duff, Khalil Choucair, Martin Oft, Mary T Albrethsen, Cherian Verghese, Lance D. Dworkin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Anemia medicine.medical_treatment Case Report Combined immunotherapy lcsh:RC254-282 Tumor response correlate 03 medical and health sciences 0302 clinical medicine Immune system Internal medicine medicine Carcinoma Lung business.industry Cancer Immunotherapy medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Clinical trial Interleukin 10 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Hyper-ferritinemia Nivolumab business |
| Zdroj: | Case Reports in Oncology, Vol 12, Iss 1, Pp 297-303 (2019) Case Reports in Oncology |
| ISSN: | 1662-6575 |
| Popis: | Anemia in cancer patients is associated with poor quality of life, reduced response to therapy, and decreased overall survival. We describe a case of a 56-year old woman with advanced metastatic non-small cell lung carcinoma who demonstrated marked response to a novel combinational immunotherapy approach involving a long-acting PEGylated construct of recombinant human Interleukin-10 with Nivolumab, an anti-PD-L1 checkpoint inhibitor. While on treatment, the patient developed severe anemia and hyper-ferritinemia requiring RBC transfusion support. Here we discuss a possible novel immune mechanism of IL10-mediated anemia in correlation with tumor response. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |