Preparation and characterization of protein-loaded polyanhydride microspheres
| Autor: | Qiuxiang Su, Lin Sun, Shaobing Zhou, Weijia Wang, Jie Weng, Xiaohong Li |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Materials science
Time Factors Surface Properties Chemical structure Polyesters Biomedical Engineering Biophysics Bioengineering Models Biological Biomaterials Gel permeation chromatography chemistry.chemical_compound Hydrolysis Polyanhydrides Polymer chemistry Absorbable Implants medicine Humans Particle Size Serum Albumin Drug Carriers Proteins Human serum albumin Biodegradable polymer Microspheres body regions Monomer chemistry Chromatography Gel Drug carrier Decanoic Acids Nuclear chemistry medicine.drug |
| Zdroj: | Journal of materials science. Materials in medicine. 20(10) |
| ISSN: | 1573-4838 |
| Popis: | Poly(1,3-bis-(p-carboxyphenoxy propane)-co-(sebacic anhydride) (P(CPP-SA)) have the anhydride bonds in copolymer backbone, which are available for degradation on the base of passive hydrolysis. This chemical structure made it degraded within a short time in linear degradation rate. For this property, polyanhydrides are one of the most suitable biodegradable polymers employed as drug carriers. This paper aimed at researching the erosion and degradation of P(CPP-SA) microspheres with CPP/SA monomer ratios of 20:80, 35:65 and 50:50. In vitro protein release from the microspheres was also investigated in this paper. Human serum albumin (HSA) was used as the model protein. In this research, the microspheres degradation and drug release rate from microspheres can be adjusted by altering the CPP/SA ratios of P(CPP-SA). The features of surface erosion were observed in SEM. The structural integrity of HSA extracted from microspheres was detected by gel permeation chromatography, compared with native HSA. The results showed HSA remained its molecule weight after encapsulated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink