Synthesis and bioactivities of novel 5,6-bis(4-methoxyphenyl)-2H-pyridazin-3-one derivatives: inhibitors of interleukin-1 beta (IL-1beta) production
| Autor: | Takayuki Matsuda, Taro Aoki, Tomoyuki Koshi, Masao Ohkuchi, Hiromichi Shigyo |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Lipopolysaccharide
Ratón Stereochemistry medicine.medical_treatment Clinical Biochemistry Drug Evaluation Preclinical Pharmaceutical Science Administration Oral HL-60 Cells Biochemistry Chemical synthesis chemistry.chemical_compound Structure-Activity Relationship In vivo Drug Discovery medicine Structure–activity relationship Animals Humans Molecular Biology Chemistry Organic Chemistry In vitro Rats Interleukin 1β Pyridazines Cytokine Drug Design Molecular Medicine Interleukin-1 |
| Zdroj: | Bioorganicmedicinal chemistry letters. 11(17) |
| ISSN: | 0960-894X |
| Popis: | New 5,6-bis(4-methoxyphenyl)-2H-pyridazin-3-one derivatives were prepared, and their abilities to inhibit IL-1beta production were evaluated. Some compounds showed potent inhibitory activity against IL-1beta production in HL-60 cells stimulated with lipopolysaccharide (LPS). The synthesis and structure-activity relationships of these compounds are described. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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