Comparison of the neuromuscular effects of mivacurium and suxamethonium in infants and children
| Autor: | Brian J. Gronert, S. K. Woelfel, D. R. Cook |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Time Factors
medicine.medical_treatment Neuromuscular Junction Nitrous Oxide Neuromuscular transmission Blood Pressure Succinylcholine Electromyography Synaptic Transmission Heart Rate Intubation Intratracheal medicine Cholinesterases Humans Intubation Child Neuromuscular Blockade Inhalation medicine.diagnostic_test business.industry Neuromuscular Effects Infant General Medicine Isoquinolines Mivacurium Anesthesiology and Pain Medicine Child Preschool Neuromuscular Depolarizing Agents Anesthesia Anesthesia Recovery Period Anesthetics Inhalation Hypotension Halothane Anesthesia Inhalation business Neuromuscular Nondepolarizing Agents medicine.drug |
| Zdroj: | Acta Anaesthesiologica Scandinavica. 39:35-40 |
| ISSN: | 1399-6576 0001-5172 |
| DOI: | 10.1111/j.1399-6576.1995.tb04307.x |
| Popis: | We compared both the time course of neuromuscular blockade and the cardiovascular side-effects of suxamethonium and mivacurium during halothane and nitrous oxide anaesthesia in infants 2-12 months and children 1-12 years of age. Equipotent doses of mivacurium and suxamethonium were studied; 2.2 x ED95 was used in four groups of infants and children, while 3.4 x ED95 was used in two groups of children. Onset of neuromuscular block in infants was not significantly faster with suxamethonium than with mivacurium (P = 0.2). In all infants given suxamethonium, intubating conditions were excellent, while, in 6/10 infants given mivacurium, intubating conditions were excellent. Onset of complete neuromuscular block in children was significantly faster with suxamethonium, 0.9 min compared with mivacurium, 1.4 min (P < or = 0.05). Increasing the dose of suxamethonium or mivacurium in children to 3.4 x ED95 did not change the onset of neuromuscular block. Recovery of neuromuscular transmission to 25% of initial twitch height (T25) in infants and children was significantly faster after suxamethonium than after mivacurium, at 2.5 and 6 min, respectively (P < or = 0.05). In children given 3.4 x ED95 of suxamethonium or mivacurium, recovery from neuromuscular block was almost identical with the dose of 2.2 x ED95, with spontaneous recovery to T25 prolonged by only 0.5 min. No infant or child had hypotension after the mivacurium bolus dose. |
| Databáze: | OpenAIRE |
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