Critical Review of Volatile Organic Compound Analysis in Breath and In Vitro Cell Culture for Detection of Lung Cancer
| Autor: | Thirumalai Venkatesan, Viknish Krishnan Kutty, Zhunan Jia, Abhijeet Patra |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Oncology
medicine.medical_specialty volatile organic compound in vitro study Endocrinology Diabetes and Metabolism lcsh:QR1-502 Review 01 natural sciences Biochemistry lcsh:Microbiology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine In vitro study Volatile organic compound breath analysis Lung cancer Molecular Biology chemistry.chemical_classification business.industry 010401 analytical chemistry medicine.disease 0104 chemical sciences lung cancer chemistry Breath gas analysis 030220 oncology & carcinogenesis Biomarker (medicine) biomarker business In vitro cell culture Lung cancer screening |
| Zdroj: | Metabolites, Vol 9, Iss 3, p 52 (2019) Metabolites |
| ISSN: | 2218-1989 |
| Popis: | Breath analysis is a promising technique for lung cancer screening. Despite the rapid development of breathomics in the last four decades, no consistent, robust, and validated volatile organic compound (VOC) signature for lung cancer has been identified. This review summarizes the identified VOC biomarkers from both exhaled breath analysis and in vitro cultured lung cell lines. Both clinical and in vitro studies have produced inconsistent, and even contradictory, results. Methodological issues that lead to these inconsistencies are reviewed and discussed in detail. Recommendations on addressing specific issues for more accurate biomarker studies have also been made. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|