Synthesis of 2-pyrazolines from pyridine based chalcone by conventional and microwave techniques: Their comparison and antimicrobial studies
| Autor: | Hemant R. Patel, Faiyazalam M. Shaikh, Navin B. Patel, Dhanji P. Rajani |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
2-Pyrazoline
Chalcone Chemistry(all) Pyridine Antimicrobial activity 030226 pharmacology & pharmacy 01 natural sciences lcsh:Chemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Organic chemistry Candida albicans Microwave irradiation biology 010405 organic chemistry General Chemistry Carbon-13 NMR Antimicrobial biology.organism_classification 0104 chemical sciences lcsh:QD1-999 chemistry Proton NMR Comparison study Microwave Nuclear chemistry |
| Zdroj: | Journal of Saudi Chemical Society, Vol 20, Iss S1, Pp S451-S456 (2016) |
| ISSN: | 1319-6103 |
| DOI: | 10.1016/j.jscs.2013.01.008 |
| Popis: | 2-Pyrazolines from pyridine based chalcones by conventional and microwave techniques have been synthesized and their antimicrobial activity as well as a comparison study between conventional and microwave techniques has been done. Antimicrobial activity was carried out according to the broth micro dilution method and it was observed that compound 2d was found to be most active against gram negative bacteria and fungus Candida albicans. Microwave technique has been found superior over the conventional method in view of reaction time and energy requirement. Compounds have been characterized by 1H NMR, 13C NMR, IR and Mass spectral analyses. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|