Correlation of increased oxidative stress to body weight in disease-free post menopausal women
| Autor: | Poonam C. Mittal, Ruchi Kant |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
medicine.medical_specialty Aging Clinical Biochemistry Body weight medicine.disease_cause Superoxide dismutase chemistry.chemical_compound Risk Factors Internal medicine Malondialdehyde medicine Odds Ratio Humans Disease Aged biology Chemistry Superoxide Dismutase Reproduction Body Weight General Medicine Odds ratio Middle Aged medicine.disease Catalase Obesity Menopause Postmenopause Oxidative Stress Endocrinology biology.protein Female Oxidative stress |
| Zdroj: | Clinical biochemistry. 42(10-11) |
| ISSN: | 1873-2933 |
| Popis: | Objectives Oxidative stress increases postmenopausally, an effect attributed to aging. Increase in body weight generally accompanies menopause. Obesity per se also seems to increase oxidative stress. The question is whether postmenopausal increase in oxidative stress is related to body weight, or is only a function of age. Design and methods Age, body weight, and superoxide dismutase (SOD), catalase (CAT) and malonyldialdehyde (MDA) in erythrocytes of a cross-section of 90 disease-free women aged 25–65 years, divided into three groups of n = 30 each of normally menstruating Controls (C), perimenopausal (periM) and postmenopausal women (postM) were recorded. Results PostM had the highest oxidative stress and body weight. SOD, CAT and MDA correlated significantly with body weight (− 0.74, 0.64 and 0.69 respectively). The odds of having a lower SOD (OR9.5, 95% CI:2.9–30.8) and higher CAT (OR6.2, 95% CI:1.6–23.0) and MDA (OR6.8, 95% CI:2.7–16.8) for weight > 60 kg was highly significant. Conclusions Oxidative stress is enhanced as body weight increases. |
| Databáze: | OpenAIRE |
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