In Search of the Most Reproducible Neural Vulnerability Factors that Predict Future Weight Gain: Analyses of Data from Six Prospective Studies
| Autor: | Ashley N. Gearhardt, Eric Stice, Sonja Yokum |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
medicine.medical_specialty Lateral Orbitofrontal Cortex 030309 nutrition & dietetics Cognitive Neuroscience Experimental and Cognitive Psychology General Medicine Replicate Striatum Audiology Vulnerability factors 03 medical and health sciences 0302 clinical medicine Replication (statistics) medicine medicine.symptom Psychology Prospective cohort study Weight gain 030217 neurology & neurosurgery |
| Zdroj: | Social cognitive and affective neuroscience. |
| ISSN: | 1749-5024 |
| Popis: | We tested if we could replicate the main effect relations of elevated striatum and lateral orbitofrontal cortex (OFC) response to high-calorie food stimuli to weight gain reported in past papers in six prospective datasets that used similar functional MRI (fMRI) paradigms. Participants in Study 1 (N = 37; M (mean) age = 15.5), Study 2 (N = 160; M age = 15.3), Study 3 (N = 130; M age = 15.0), Study 4 (N = 175; M age = 14.3), Study 5 (N = 45; M age = 20.8) and Study 6 (N = 49; M age = 31.1) completed fMRI scans at the baseline and had their body mass index (BMI) and body fat (Studies 4 and 6 only) measured at the baseline and over follow-ups. Elevated striatal response to palatable food images predicted BMI gain in Studies 1 and 6 and body fat gain in Study 6. Lateral OFC activation did not predict weight gain in any of the six studies. The result provide limited support for the hypothesis that elevated reward region responsivity to palatable food images predicts weight gain. Factors that make replication difficult are discussed and potential solutions considered. |
| Databáze: | OpenAIRE |
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