Apolipoprotein E DNA methylation and posttraumatic stress disorder are associated with plasma ApoE level: A preliminary study
| Autor: | David A. Nielsen, Mark J. Harding, David P. Graham, Catherine J. Spellicy |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Apolipoprotein E
Male medicine.medical_specialty Heterozygote Apolipoprotein B Genotype Traumatic brain injury Apolipoprotein E4 Apolipoprotein E3 Stress Disorders Post-Traumatic 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Apolipoproteins E Risk Factors Internal medicine medicine Humans Alleles 030304 developmental biology 0303 health sciences biology business.industry Promoter Methylation DNA Methylation medicine.disease humanities Endocrinology CpG site DNA methylation biology.protein lipids (amino acids peptides and proteins) Female business 030217 neurology & neurosurgery |
| Zdroj: | Behavioural brain research. 356 |
| ISSN: | 1872-7549 |
| Popis: | Mild traumatic brain injury (mTBI) occurred in 15–30% of Veterans returning from Iraq and Afghanistan. We examined whether DNA methylation of the apolipoprotein E (APOE) gene promoter region or plasma ApoE protein levels are altered in mTBI. APOE promoter region DNA methylation, APOE genotype, and plasma ApoE concentration were determined in 87 Veterans with or without mTBI who were recruited from 2010-2014. Plasma ApoE concentration was found to be associated with Posttraumatic Stress Disorder (PTSD) symptom severity ratings by hierarchical linear regression (p = .013) and ANCOVA (p = .007). Hierarchical linear regression revealed that plasma ApoE concentration was associated with APOE-e4 genotype status (p=.022). Higher ApoE plasma levels were found in e3/e3 Veterans than in APOE-e4 carriers (p = .031). Furthermore, plasma ApoE concentration was associated experiment-wise with DNA methylation at CpG sites -877 (p = .021), and -775 (p = .014). The interaction between APOE-e4 genotype and having a PTSD diagnosis was associated with DNA methylation at CpG site -675 (p = .009). |
| Databáze: | OpenAIRE |
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